PUBLICATION
A noncanonical path to mechanism of action
- Authors
- Peterson, R.T.
- ID
- ZDB-PUB-060922-1
- Date
- 2006
- Source
- Chemistry & Biology 13(9): 924-926 (Journal)
- Registered Authors
- Peterson, Randall
- Keywords
- none
- MeSH Terms
-
- Aminopeptidases/antagonists & inhibitors
- Aminopeptidases/genetics
- Aminopeptidases/metabolism*
- Angiogenesis Inhibitors/pharmacology*
- Animals
- Cell Line, Tumor
- Cyclohexanes/pharmacology*
- Embryonic Development/drug effects
- Fatty Acids, Unsaturated/pharmacology*
- Metalloendopeptidases/antagonists & inhibitors
- Metalloendopeptidases/genetics
- Metalloendopeptidases/metabolism*
- Mice
- Phenotype
- RNA, Antisense
- Sesquiterpenes/pharmacology*
- Signal Transduction/drug effects
- Wnt Proteins/genetics
- Wnt Proteins/metabolism*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 16984880 Full text @ Chem. Biol.
Citation
Peterson, R.T. (2006) A noncanonical path to mechanism of action. Chemistry & Biology. 13(9):924-926.
Abstract
Improved methods for discovering small-molecule mechanisms of action are needed. In this issue of Chemistry & Biology, Zhang et al. make clever use of the zebrafish to study the mechanism of the angiogenesis inhibitor fumagillin and reveal that it targets the noncanonical Wnt pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping