ZFIN ID: ZDB-PUB-060508-18
The embryonic vertebrate heart tube is a dynamic suction pump
Forouhar, A.S., Liebling, M., Hickerson, A., Nasiraei-Moghaddam, A., Tsai, H.J., Hove, J.R., Fraser, S.E., Dickinson, M.E., and Gharib, M.
Date: 2006
Source: Science (New York, N.Y.)   312(5774): 751-753 (Journal)
Registered Authors: Forouhar, Arian S., Fraser, Scott E., Hove, Jay R., Liebling, Michael, Tsai, Huai-Jen
Keywords: none
MeSH Terms:
  • Animals
  • Biomechanical Phenomena
  • Cardiac Output*
  • Heart/embryology*
  • Heart/physiology*
  • Microscopy, Confocal
  • Models, Cardiovascular
  • Myocardial Contraction*
  • Pressure
  • Zebrafish/embryology*
PubMed: 16675702 Full text @ Science
ABSTRACT
The embryonic vertebrate heart begins pumping blood long before the development of discernable chambers and valves. At these early stages, the heart tube has been described as a peristaltic pump. Recent advances in confocal laser scanning microscopy and four-dimensional visualization have warranted another look at early cardiac structure and function. We examined the movement of cells in the embryonic zebrafish heart tube and the flow of blood through the heart and obtained results that contradict peristalsis as a pumping mechanism in the embryonic heart. We propose a more likely explanation of early cardiac dynamics in which the pumping action results from suction due to elastic wave propagation in the heart tube.
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