PUBLICATION

Accumulation and elimination of cadmium in larval stage zebrafish following acute exposure

Authors
Matz, C.J., Treble, R.G., and Krone, P.H.
ID
ZDB-PUB-060105-13
Date
2007
Source
Ecotoxicology and environmental safety   66(1): 44-48 (Journal)
Registered Authors
Krone, Patrick H.
Keywords
Zebrafish larvae, Cadmium, Bioaccumulation
MeSH Terms
  • Animals
  • Cadmium/metabolism*
  • Cadmium/toxicity
  • Larva/drug effects
  • Larva/metabolism
  • Toxicity Tests
  • Zebrafish/growth & development
  • Zebrafish/metabolism*
PubMed
16376426 Full text @ Ecotoxicol. Environ. Saf.
Abstract
A number of recent studies have examined the impact of acute cadmium exposure on early zebrafish development at the morphological, cellular, and molecular levels. However, no information on the accumulation and elimination of cadmium during early life stages of zebrafish development has been available. Here we have quantified cadmium accumulation in larval zebrafish (Danio rerio) by graphite furnace atomic absorption spectroscopy following short-term acute exposure and recovery periods. Zebrafish (80h postfertilization) were exposed to various concentrations of cadmium (0.2, 1.0, 5.0, 25, 125muM) for 3h. Cadmium accumulation in larvae increased with exposure concentration. After exposure at 5.0, 25, and 125muM cadmium, the fish were allowed to recover in freshwater for 0, 12, or 24h. Cadmium content did not show a statistically significant decrease over the recovery period when exposed to 5.0 or 25muM cadmium, whereas significant losses over the recovery period were observed following 125muM exposure. These results suggest that the larval zebrafish decrease total cadmium body burden only following relatively high short-term acutely toxic exposures.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping