ZFIN ID: ZDB-PUB-051128-11
Chemical Genetics: Drug Screens in Zebrafish
den Hertog, J.
Date: 2005
Source: Bioscience Reports   25(5-6): 289-297 (Journal)
Registered Authors: den Hertog, Jeroen
Keywords: Chemical genetics, zebrafish, development, compounds, inhibitors, drug target, disease
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Drug Evaluation, Preclinical/methods*
  • Models, Biological
  • Models, Genetic
  • Mutagenesis
  • Pharmacogenetics/methods*
  • Toxicity Tests
  • Zebrafish/embryology
  • Zebrafish/metabolism*
  • Zebrafish/physiology*
PubMed: 16307377 Full text @ Biosci. Rep.
High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb zebrafish development. Chemical genetics using zebrafish embryos may become an important step in the discovery of drugs and their targets.