ZFIN Person: den Hertog, Jeroen

ZFIN ID: ZDB-PERS-040713-1

den Hertog, Jeroen

Email:	hertog@niob.knaw.nl
URL:	http://www.niob.knaw.nl/researchpages/denhertog/groupleader.html
Affiliation:	den Hertog Lab
Address:	Hubrecht Laboratory Uppsalalaan 8 Utrecht, 3584 CT Netherlands
Country:	Netherlands
Phone:	31 30 2121800
Fax:	31 30 2516464
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Allers, M., Bakker, P.A., Hoeksma, J., Spaink, H.P., den Hertog, J. (2023) Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Disease models & mechanisms. 16(2):

Solman, M., Woutersen, D.T.J., den Hertog, J. (2022) Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2. Frontiers in cell and developmental biology. 10:1046415

Solman, M., Blokzijl-Franke, S., Piques, F., Yan, C., Yang, Q., Strullu, M., Kamel, S.M., Ak, P., Bakkers, J., Langenau, D.M., Cave, H., den Hertog, J. (2022) Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. eLIFE. 11:

Bobone, S., Pannone, L., Biondi, B., Solman, M., Flex, E., Canale, V.C., Calligari, P., De Faveri, C., Gandini, T., Quercioli, A., Torini, G., Venditti, M., Lauri, A., Fasano, G., Hoeksma, J., Santucci, V., Cattani, G., Bocedi, A., Carpentieri, G., Tirelli, V., Sanchez, M., Peggion, C., Formaggio, F., den Hertog, J., Martinelli, S., Bocchinfuso, G., Tartaglia, M., Stella, L. (2021) Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions. Journal of medicinal chemistry. 64(21):15973-15990

Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755

Leijten, N.M., Bakker, P., Spaink, H.P., den Hertog, J., Lemeer, S. (2021) Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism. Molecular & cellular proteomics : MCP. 20:100033

Hoeksma, J., van der Zon, G.C.M., Ten Dijke, P., den Hertog, J. (2020) Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish. Disease models & mechanisms. 13(9):

Hoeksma, J., Misset, T., Wever, C., Kemmink, J., Kruijtzer, J., Versluis, K., Liskamp, R.M.J., Boons, G.J., Heck, A.J.R., Boekhout, T., den Hertog, J. (2019) A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Scientific Reports. 9:17546

Hale, A.J., den Hertog, J. (2017) Shp2-MAPK signalling drives proliferation during zebrafish embryo caudal fin-fold regeneration. Molecular and cellular biology. 38(4):e00515-17

Hale, A.J., Kiai, A., Sikkens, J., den Hertog, J. (2017) Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten. Regeneration (Oxford, England). 4:217-226

Ciarlo, C., Kaufman, C.K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T.M., Zhou, Y., Liao, E., Zon, L.I. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. eLIFE. 6

Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460

Blokhuis, A.M., Koppers, M., Groen, E.J., van den Heuvel, D.M., Dini Modigliani, S., Anink, J.J., Fumoto, K., van Diggelen, F., Snelting, A., Sodaar, P., Verheijen, B.M., Demmers, J.A., Veldink, J.H., Aronica, E., Bozzoni, I., den Hertog, J., van den Berg, L.H., Pasterkamp, R.J. (2016) Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. Acta Neuropathologica. 132(2):175-96

Stumpf, M., Blokzijl-Franke, S., den Hertog, J. (2016) Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis. PLoS One. 11:e0154771

Stumpf, M., den Hertog, J. (2016) Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One. 11:e0148508

Hale, A.J., den Hertog, J. (2016) Studying Protein-Tyrosine Phosphatases in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1447:351-72

den Hertog, J. (2016) Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond. Advances in experimental medicine and biology. 916:87-101

Stumpf, M., Choorapoikayil, S., den Hertog, J. (2015) Pten function in zebrafish: anything but a fish story. Methods (San Diego, Calif.). 77-78:191-6

Vissers, L.E., Bonetti, M., Paardekooper Overman, J., Nillesen, W.M., Frints, S.G., de Ligt, J., Zampino, G., Justino, A., Machado, J.C., Schepens, M., Brunner, H.G., Veltman, J.A., Scheffer, H., Gros, P., Costa, J.L., Tartaglia, M., van der Burgt, I., Yntema, H.G., den Hertog, J. (2015) Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. European journal of human genetics : EJHG. 23(3):317-24

Paardekooper Overman, J., Yi, J.S., Bonetti, M., Soulsby, M., Preisinger, C., Stokes, M.P., Hui, L., Silva, J.C., Overvoorde, J., Giansanti, P., Heck, A.J., Kontaridis, M.I., den Hertog, J., Bennett, A.M. (2014) PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice. Molecular and cellular biology. 34(15):2874-89

Bonetti, M., Paardekooper Overman, J., Tessadori, F., Noël, E., Bakkers, J., den Hertog, J. (2014) Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development (Cambridge, England). 141:1961-70

Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53

Choorapoikayil, S., Kers, R., Herbomel, P., Kissa, K., and den Hertog, J. (2014) Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood.

Choorapoikayil, S., Weijts, B., Kers, R., de Bruin, A., and den Hertog, J. (2013) Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish. Disease models & mechanisms. 6(5):1159-66

Choorapoikayil, S., Overvoorde, J., and den Hertog, J. (2013) Deriving Cell Lines from Zebrafish Embryos and Tumors. Zebrafish. 10(3):316-25

Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H.P., Schaaf, M.J., and Meijer, A.H. (2013) Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 190(4):1631-1645

Guida, V., Ferese, R., Rocchetti, M., Bonetti, M., Sarkozy, A., Cecchetti, S., Gelmetti, V., Lepri, F., Copetti, M., Lamorte, G., Digilio, C.M., Marino, B., Zaza, A., den Hertog, J., Dallapiccola, B., and De Luca, A. (2013) A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot. European journal of human genetics : EJHG. 21(1):69-75

Noël, E.S., Verhoeven, M., Lagendijk, A.K., Tessadori, F., Smith, K., Choorapoikayil, S., den Hertog, J., and Bakkers, J. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature communications. 4:2754

Choorapoikayil, S., Kuiper, R.V., de Bruin, A., and den Hertog, J. (2012) Haploinsufficiency of tumor suppressor pten predisposes to hemangiosarcoma in zebrafish. Disease models & mechanisms. 5(2):241-247

Runtuwene, V., van Eekelen, M., Overvoorde, J., Rehmann, H., Yntema, H.G., Nillesen, W.M., van Haeringen, A., van der Burgt, I., Burgering, B., and den Hertog, J. (2011) Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects. Disease models & mechanisms. 4(3):393-399

van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573

van Eekelen, M., Runtuwene, V., Overvoorde, J., and den Hertog, J. (2010) RPTPalpha and PTPepsilon Signaling via Fyn/Yes and RhoA is Essential for Zebrafish Convergence and Extension Cell Movements during Gastrulation. Developmental Biology. 340(2):626-639

Rodriguez, F., Vacaru, A., Overvoorde, J., and den Hertog, J. (2008) The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development. Developmental Biology. 324(1):122-130

Lemeer, S., Jopling, C., Gouw, J.W., Mohammed, S., Heck, A.J., Slijper, M., and den Hertog, J. (2008) Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Molecular & cellular proteomics : MCP. 7(11):2176-2187

Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564

Faucherre, A., Taylor, G.S., Overvoorde, J., Dixon, J.E., and Hertog, J.D. (2008) Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development. Oncogene. 27(8):1079-1086

Jopling, C., van Geemen, D., and den Hertog, J. (2007) Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2-Induced Gastrulation Defects. PLoS Genetics. 3(12):e225

Lemeer, S.M., Ruijtenbeek, R., Pinkse, M.W., Jopling, C., Heck, A.J., den Hertog, J., and Slijper, M. (2007) Endogenous phosphotyrosine signaling in zebrafish embryos. Molecular & cellular proteomics : MCP. 6(12):2088-2099

Knöll, R., Postel, R., Wang, J., Krätzner, R., Hennecke, G., Vacaru, A.M., Vakeel, P., Schubert, C., Murthy, K., Rana, B.K., Kube, D., Knöll, G., Schäfer, K., Hayashi, T., Holm, T., Kimura, A., Schork, N., Toliat, M.R., Nürnberg, P., Schultheiss, H.P., Schaper, W., Schaper, J., Bos, E., den Hertog, J., van Eeden, F.J., Peters, P.J., Hasenfuss, G., Chien, K.R., and Bakkers, J. (2007) Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 116(5):515-525

Lemeer, S., Jopling, C., Naji, F., Ruijtenbeek, R., Slijper, M., Heck, A.J., and den Hertog, J. (2007) Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. PLoS One. 2(1):e581

Jopling, C., and den Hertog, J. (2007) Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation. Mechanisms of Development. 124(2):129-136

Diks, S.H., Bink, R.J., van de Water, S., Joore, J., van Rooijen, C., Verbeek, F.J., den Hertog, J., Peppelenbosch, M.P., and Zivkovic, D. (2006) The novel gene asb11: a regulator of the size of the neural progenitor compartment. The Journal of cell biology. 174(4):581-592

den Hertog, J. (2005) Chemical Genetics: Drug Screens in Zebrafish. Bioscience Reports. 25(5-6):289-297

Jopling, C., and den Hertog, J. (2005) Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO reports. 6(5):426-431

Bink, R.J., Habuchi, H., Lele, Z., Dolk, E., Joore, J., Rauch, G.J., Geisler, R., Wilson, S.W., den Hertog, J., Kimata, K., and Zivkovic, D. (2003) Heparan sulfate 6-O-sulfotransferase is essential for muscle development in zebrafish. The Journal of biological chemistry. 278(33):31118-31127

van der Sar, A.M., Zivkovic, D., and den Hertog, J. (2002) Eye defects in receptor protein-tyrosine phosphatase alpha knock-down zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(2):292-297

van der Sar, A., Betist, M., de Fockert, J., Overvoorde, J., Zivkovic, D., and den Hertog, J. (2001) Expression of receptor protein-tyrosine phosphatase alpha, sigma and LAR during development of the zebrafish embryo. Mechanisms of Development. 109(2):423-426

van der Sar, A.M., de Fockert, J., Betist, M., Zivkovic, D., and den Hertog, J. (1999) Pleiotropic effects of zebrafish protein-tyrosine phosphatase-1B on early embryonic development. The International journal of developmental biology. 43(8):785-794

NON-ZEBRAFISH PUBLICATIONS