PUBLICATION
cadherin-6 Message expression in the nervous system of developing zebrafish
- Authors
- Liu, Q., Liu, B., Wilson, A.L., and Rostedt, J.
- ID
- ZDB-PUB-051101-17
- Date
- 2006
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 235(1): 272-278 (Journal)
- Registered Authors
- Liu, Qin
- Keywords
- zebrafish, development, cell adhesion molecules, brain, cranial ganglia, lateral line system
- MeSH Terms
-
- Animals
- Cadherins/biosynthesis*
- Cadherins/genetics*
- Central Nervous System/chemistry
- Central Nervous System/metabolism*
- Peripheral Nervous System/chemistry
- Peripheral Nervous System/metabolism*
- RNA, Messenger/biosynthesis*
- RNA, Messenger/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics*
- Zebrafish/metabolism
- PubMed
- 16258934 Full text @ Dev. Dyn.
Citation
Liu, Q., Liu, B., Wilson, A.L., and Rostedt, J. (2006) cadherin-6 Message expression in the nervous system of developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(1):272-278.
Abstract
Cadherins are cell surface adhesion molecules that play important roles in development of a variety of tissues including the nervous system. In this study, we analyzed expression pattern of cadherin-6, a member of the type II cadherin subfamily, in the embryonic zebrafish nervous system using in situ hybridization methods. cadherin-6 message is first expressed by the neural keel, then by restricted regions in the brain and spinal cord. cadherin-6 expression in the brain transiently delineates specific brain regions. In the peripheral nervous system, cadherin-6 message is expressed by the neurogenic placodes and the dorsal root ganglia. As development proceeds, cadherin-6 expression domain and/or expression levels increased in the embryonic nervous system. Our results show that cadherin-6 expression in the zebrafish developing nervous system is both spatially and temporally regulated, implicating a role for cadherin-6 in the formation of these nervous structures.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping