PUBLICATION
Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo
- Authors
- Ingham, P.W., and Kim, H.R.
- ID
- ZDB-PUB-050607-3
- Date
- 2005
- Source
- Experimental cell research 306(2): 336-342 (Review)
- Registered Authors
- Ingham, Philip, Kim, Rosemary
- Keywords
- Hedgehog signalling; Zebrafish; Muscle cell; Blimp1; Slow twitch fibre
- MeSH Terms
-
- Animals
- Cell Differentiation
- DNA-Binding Proteins
- Embryo, Nonmammalian/metabolism*
- Embryonic Induction
- Gene Expression Regulation, Developmental/physiology*
- Hedgehog Proteins
- Muscle, Skeletal/embryology*
- Nuclear Proteins
- Repressor Proteins/metabolism
- Signal Transduction/physiology*
- Trans-Activators/physiology*
- Transcription Factors/metabolism
- Zebrafish/embryology*
- Zebrafish Proteins
- PubMed
- 15925589 Full text @ Exp. Cell Res.
Citation
Ingham, P.W., and Kim, H.R. (2005) Hedgehog signalling and the specification of muscle cell identity in the Zebrafish embryo. Experimental cell research. 306(2):336-342.
Abstract
Signalling by members of the Hedgehog family of secreted proteins plays a central role in the development of many animal species. In the zebrafish embryo, the specification of myoblast fates is controlled by Hedgehog signals emanating from axial midline structures. Distinct muscle cell identities are induced by varying levels of signalling activity. The SET domain transcription factor, Blimp1, is a key target of Hedgehog signalling in this process.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping