PUBLICATION

Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis

Authors
Hogan, B.M., Danks, J.A., Layton, J.E., Hall, N.E., Heath, J.K., and Lieschke, G.J.
ID
ZDB-PUB-041115-6
Date
2005
Source
Endocrinology   146(2): 547-551 (Journal)
Registered Authors
Heath, Joan K., Hogan, Ben M., Layton, Judy E., Lieschke, Graham J.
Keywords
none
MeSH Terms
  • Afferent Pathways/embryology
  • Afferent Pathways/physiology*
  • Animal Structures/embryology
  • Animal Structures/physiology
  • Animals
  • Central Nervous System/embryology
  • Central Nervous System/physiology*
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental*
  • Male
  • Mechanoreceptors/physiology
  • Parathyroid Glands
  • Parathyroid Hormone/genetics*
  • Zebrafish/embryology
  • Zebrafish/physiology*
PubMed
15539562 Full text @ Endocrinology
Abstract
Parathyroid hormone (PTH) plays a critical role in calcium metabolism in tetrapods. The primary site of PTH expression is the parathyroid glands, although it is also detected in the thymus and hypothalamus. Fish lack anatomically distinct parathyroid glands and the first animals to evolve parathyroid glands were the amphibians. However, fish do have PTH family ligands and receptors, which are functionally similar to their mammalian counterparts. We report the expression patterns of duplicate zebrafish pth genes during embryogenesis. Both zebrafish pth1 and pth2 transcripts are expressed along the lateral line before the migration of the lateral line primordium and later in development Pth protein is detected in lateral line neuromasts by immunohistochemistry. pth1 transcripts are also detected in the central nervous system, in the ventral neural tube. These temporally and anatomically restricted expression patterns imply a novel role for PTH family hormones during embryonic development of the zebrafish and allow for the genetic dissection of PTH function in this model organism.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping