Biography and Research Interest

Zebrafish intestinal development
Genetic regulation of colon cancer
RNA splicing
RNA binding proteins
Gene expression

Publications

Non-Zebrafish Publications

Johnston APR, Kamphuis MMJ, Such GK, Scott AM, Nice EC, Heath JK, Caruso F (2012). Targeting cancer cells: controlling the binding and internalization of antibody-functionalized capsules. ACS Nano 6:6667-6674

Shimoni O, Postma A, Yan Y, Scott AM, Heath JK, Nice EC, Zelikin AN, Caruso F (2012). Macromolecule functionalization of redox-active hydrogel capsules and cancer cell targeting. ACS Nano 6:1463-1472

Yan Y, Wang Y, Heath JK, Nice EC, Caruso F. Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols (2011). Adv Mater 23:3916-3921

Heath JK (2010) Transcriptional networks and signaling pathways that govern vertebrate intestinal development. Invited Review: In Current Topics in Developmental Biology Volume 90. Organogenesis in Development. (Ed. Peter Koopman, Elsevier) pp 159-192.

Kamphuis, MMJ, Johnston APR, Such GK, Dam HH, Evans RA, Scott AM, Nice EC, Heath JK and Caruso F (2010). Targeting of cancer cells using click-functionalized polymer capsules. J Am Chem Soc 132:15881-3

Yan Y, Ochs CJ, Such GK, Heath JK, Nice EC, Caruso F (2010). Bypassing multidrug resistance in cancer cells with biodegradable polymer capsules. Adv Mater. 22:5398-5403

Wang Y, Yan Y, Cui J, Hosta-Rigau L, Heath JK, Nice EC, Caruso F (2010). Encapsulation of water-insoluble drugs in polymer capsules prepared using mesoporous silica templates for intracellular drug delivery. Adv Mater 22(38):4293-4297

Yan Y, Johnston AP, Dodds SJ, Kamphuis MM, Ferguson C, Parton RG, Nice EC, Heath JK,* Caruso F* (2010). Uptake and intracellular fate of disulfide-bonded polymer hydrogel capsules for doxorubicin delivery to colorectal cancer cells. ACS Nano 4:2928-2936. *denotes equal contribution

Buchert M,* Athineos D,* Abud HE,* Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, N�thke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Owen J. Sansom OJ, Ernst M (2010). Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo. PLoS Genet. Jan 15;6(1):e1000816. *denotes equal contribution

Pereira-Fantini PM, Judd LM, Kalantzis A, Peterson AA, Ernst M, Heath JK and Giraud AS (2010). A33 antigen-deficient mice have defective colonic mucosal repair. Inflammatory Bowel Disease 16:604-12

Hosta-Rigau L, St�dler B, Yan Yan, Nice EC, Heath JK, Albericio F and Caruso F (2010). Capsosomes with multilayered subcompartments: assembly and loading with hydrophobic cargo. In press, Advanced Functional Materials 20:59-66

Samuel MS, Suzuki H,, Buchert M, Putoczki TL, Tebbutt NC, Lundgren-May T, Christou A, Inglese M, Toyota M, Heath JK, Ward RL, Waring PW and Ernst M (2009). Elevated Dnmt3a activity promotes polyposis in ApcMin mice by relaxing extracellular restraints on Wnt signaling. Gastroenterology 137:902-913

B�ning J, von Smolinski D, Tafazzoli K, Zimmer KP, Strobel S, Apostolaki M, Kollias G, Heath JK, Ludwig D, Gebert A (2008). Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II-restricted antigen processing and origin of exosomes. Immunology 125: 510–521

Cortez C, Tomaskovic-Crook E, Johnston APR, Scott AM, Nice EC, Heath JK, Caruso F (2007). Influence of size, surface, cell line and kinetic properties on the specific binding of A33 antigen-targeted multilayered particles to colorectal cancer cells. ACS Nano 1:93–102

Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, Dworkin S, Heath JK, Frampton J, McArthur G, Clevers H, Hilton D, Mantamadiotis T, Ramsay RG 2007.
c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci USA 104:3829-3834

Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, Yonekura AR, Heath JK, Turley SJ 2007.
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol. 2007 8:181-90

Cortez C, Tomaskovic-Crook E, Johnston A.P.R., Radt B, Cody S.H., Scott A.M., Nice E.C., Heath J.K., Caruso F 2006.
Targeting and uptake of multilayered particles to colorectal cancer cells. Advanced Materials 18: 1998-2003

Abud HE, Watson N, Heath JK 2005.
Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp Cell Res 303:252-262

Cody SH, Xiang SD, Layton MJ, Handman E, Lam MH, Layton JE, Nice EC, Heath JK 2005.
A simple method allowing DIC imaging in conjunction with confocal microscopy. J Microsc. 217:265-74

Abud HE, Lock P, Heath JK 2004.
Efficient gene transfer into the epithelial cell layer of embryonic mouse intestine using low-voltage electroporation. Gastroenterology 126:1779-87

Abud HE, Heath JK 2004.
Detecting apoptosis during the formation of polarized intestinal epithelium in organ culture. Cell Death Differ11:788-9

Miller ME, Michaylira CZ, Simmons JG, Ney DM, Dahly EM, Heath JK, Lund PK 2004.
Suppressor of cytokine signaling-2: a growth hormone-inducible inhibitor of intestinal epithelial cell proliferation. Gastroenterology 127:570-81.

Ramsay RG, Micallef SJ, Williams B, Lightowler S, Vincan E, Heath JK, Mantamadiotis T, Bertoncello I 2004.
Colony-stimulating factor-1 promotes clonogenic growth of normal murine colonic crypt epithelial cells in vitro. J Interferon Cytokine Res 24:416-27