Chitnis, A.B., and Itoh, M. (2004) Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations. Current opinion in genetics & development. 14(4):415-421.
The StarLogo and NetLogo programming environments allow developmental biologists to build computer models of cell–cell interactions in an epithelium and visualize emergent properties of hypothetical genetic regulatory networks operating in the cells. These environments were used to explore alternative models that show how a posteriorizing morphogen gradient might define gene-expression domains along the rostral–caudal axis in the zebrafish neurectoderm. The models illustrate how a hypothetical genetic network based on auto-activation and cross-repression could lead to establishment of discrete non-overlapping gene-expression domains.