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ZFIN ID: ZDB-PERS-970618-17
Itoh, Motoyuki
Email: mito@chiba-u.jp
Affiliation: Itoh Lab
Address: Research bldg1. Rm.308, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675 Graduate School of Pharmaceutical Sciences, Chiba University
Country: United States
Phone: +81- 43-226-2890
Fax: +81- 43-226-2890
Orcid ID:


Kuwabara, S., Yamaki, M., Yu, H., Itoh, M. (2018) Notch signaling regulates the expression of glycolysis-related genes in a context-dependent manner during embryonic development. Biochemical and Biophysical Research Communications. 503(2):803-808
Mizoguchi, T., Ikeda, S., Watanabe, S., Sugawara, M., Itoh, M. (2017) Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway. Proc. Natl. Acad. Sci. USA. 114(44):E9280-E9289
Yang, P., Kajiwara, R., Tonoki, A., Itoh, M. (2017) Successive and discrete spaced conditioning in active avoidance learning in young and aged zebrafish. Neurosciences research. 130:1-7
Matsuda, M., Rand, K., Palardy, G., Shimizu, N., Ikeda, H., Nogare, D.D., Itoh, M., Chitnis, A.B. (2016) Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. Development (Cambridge, England). 143(17):3085-96
Mizoguchi, T., Kawakami, K., Itoh, M. (2016) Zebrafish lines expressing UAS-driven red probes for monitoring cytoskeletal dynamics. Genesis (New York, N.Y. : 2000). 54(9):483-9
Kawakami, K., Asakawa, K., Hibi, M., Itoh, M., Muto, A., Wada, H. (2016) Gal4 Driver Transgenic Zebrafish: Powerful Tools to Study Developmental Biology, Organogenesis, and Neuroscience. Advances in genetics. 95:65-87
Mikami, S., Nakaura, M., Kawahara, A., Mizoguchi, T., Itoh, M. (2015) Mindbomb 2 is dispensable for embryonic development and Notch signalling in zebrafish. Biology Open. 4(11):1576-82
Ohishi, K., Toume, K., Arai, M.A., Koyano, T., Kowithayakorn, T., Mizoguchi, T., Itoh, M., Ishibashi, M. (2015) 9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α. Journal of natural products. 78(5):1139-46
Ohishi, K., Toume, K., Arai, M.A., Sadhu, S.K., Ahmed, F., Mizoguchi, T., Itoh, M., Ishibashi, M. (2014) Ricinine: A pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α. Bioorganic & Medicinal Chemistry. 22(17):4597-601
Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
Itoh, M., Nakaura, M., Imanishi, T., and Obika, S. (2014) Target Gene Knockdown by 2',4'-BNA/LNA Antisense Oligonucleotides in Zebrafish. Nucleic Acid Therapeutics. 24(3):186-91
Ota, S., Ishitani, S., Shimizu, N., Matsumoto, K., Itoh, M., and Ishitani, T. (2012) NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. The EMBO journal. 31(8):1904-1915
Hozumi, S., Hirabayashi, R., Yoshizawa, A., Ogata, M., Ishitani, T., Tsutsumi, M., Kuroiwa, A., Itoh, M., and Kikuchi, Y. (2012) DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish. PLoS One. 7(3):e33675
Mizoguchi, T., Togawa, S., Kawakami, K., and Itoh, M. (2011) Neuron and sensory epithelial cell fate is sequentially determined by notch signaling in zebrafish lateral line development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(43):15522-15530
Yamamoto, M., Morita, R., Mizoguchi, T., Matsuo, H., Isoda, M., Ishitani, T., Chitnis, A.B., Matsumoto, K., Crump, J.G., Hozumi, K., Yonemura, S., Kawakami, K., and Itoh, M. (2010) Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development (Cambridge, England). 137(15):2527-2537
Ishitani, T., Hirao, T., Suzuki, M., Isoda, M., Ishitani, S., Harigaya, K., Kitagawa, M., Matsumoto, K., and Itoh, M. (2010) Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nature cell biology. 12(3):278-285
Tsutsumi, M., and Itoh, M. (2007) Novel transcript nort is a downstream target gene of the Notch signaling pathway in zebrafish. Gene expression patterns : GEP. 793):227-232
Ishitani, T., Matsumoto, K., Chitnis, A.B., and Itoh, M. (2005) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nature cell biology. 7(11):1106-1112
Chitnis, A.B., and Itoh, M. (2004) Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations. Current opinion in genetics & development. 14(4):415-421
Bingham, S., Chaudhari, S., Vanderlaan, G., Itoh, M., Chitnis, A., and Chandrasekhar, A. (2003) Neurogenic phenotype of mind bomb mutants leads to severe patterning defects in the zebrafish hindbrain. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):451-463
Dorsky, R.I., Itoh, M., Moon, R.T., and Chitnis, A. (2003) Two tcf3 genes cooperate to pattern the zebrafish brain. Development (Cambridge, England). 130(9):1937-1947
Geling, A., Itoh, M., Tallafuss, A., Chapouton, P., Tannhauser, B., Kuwada, J.Y., Chitnis, A.B., and Bally-Cuif, L. (2003) bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary. Development (Cambridge, England). 130(8):1591-1604
Itoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G.J., Ariza-McNaughton, L., Weissman, A.M., Lewis, J., Chandrasekharappa, S.C., and Chitnis, A.B. (2003) Mind Bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by Delta. Developmental Cell. 4(1):67-82
Itoh, M., Kudoh, T., Dedekian, M., Kim, C.-H., and Chitnis, A.J. (2002) A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development (Cambridge, England). 129(10):2317-2327
Itoh, M. and Chitnis, A.B. (2001) Expression of proneural and neurogenic genes in the zebrafish lateral line primordium correlates with selection of hair cell fate in neuromasts. Mechanisms of Development. 102(1-2):263-266
Kim, C.H., Oda, T., Itoh, M., Jiang, D., Artinger, K.B., Chandrasekharappa, S.C., Driever, W., and Chitnis, A.B. (2000) Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature. 407(6806):913-916
Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T. (2000) Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Developmental Biology. 217(1):138-152