PUBLICATION

Zebrafish beta tubulin 1 expression is limited to the nervous system throughout development, and in the adult brain is restricted to a subset of proliferative regions

Authors
Oehlmann, V.D., Berger, S., Sterner, C., and Korsching, S.I.
ID
ZDB-PUB-040601-7
Date
2004
Source
Gene expression patterns : GEP   4(2): 191-198 (Journal)
Registered Authors
Berger, Sandra M., Korsching, Sigrun, Oehlmann, Verena D.
Keywords
none
MeSH Terms
  • Animals
  • Base Sequence
  • Brain/embryology*
  • Brain/metabolism*
  • Cell Division/physiology
  • Evolution, Molecular
  • Gene Expression/physiology*
  • Gene Expression Profiling
  • Molecular Sequence Data
  • Olfactory Bulb/metabolism
  • Phylogeny
  • Tubulin/genetics*
  • Tubulin/metabolism*
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish/metabolism
PubMed
15161099 Full text @ Gene Expr. Patterns
Abstract
Tubulin, the building block of microtubules, consists of an alpha and beta subunit, each in itself a family of several highly homologous isotypes. Abundance, tissue specificity, developmental regulation, and possibly function vary between isotypes. Six isotypes of beta tubulin (class I to class VI) have been cloned from several vertebrate species. Class I beta tubulin is believed to be widely expressed, but has not been studied by in situ hybridization in any vertebrate species so far. We have cloned a beta tubulin from zebrafish that appears most similar to other vertebrate class I tubulins and name it zbeta1 tubulin, accordingly. We report a distinct expression pattern of zbeta1 tubulin in the zebrafish embryo in restricted regions of the peripheral and central nervous system that comprise early-differentiating neurons. The expression pattern changes during development and in the adult zebrafish expression mostly is confined to a subset of proliferative zones that include the subependymal zone around the telencephalic ventricle, zones in the preoptic and hypothalamic area and in the olfactory epithelium. Thus, zbeta1 tubulin is expressed with remarkable selectivity during neuronal differentiation and neurogenesis in the embryonic and adult nervous system, respectively.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping