PUBLICATION
The use of zebrafish to understand immunity
- Authors
- Trede, N.S., Langenau, D.M., Traver, D., Look, A.T., and Zon, L.I.
- ID
- ZDB-PUB-040416-5
- Date
- 2004
- Source
- Immunity 20(4): 367-379 (Journal)
- Registered Authors
- Langenau, David, Look, A. Thomas, Traver, David, Trede, Nick, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Lineage/immunology
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Gene Expression
- Immunity, Innate*
- Mice
- Zebrafish/immunology*
- PubMed
- 15084267 Full text @ Immunity
Citation
Trede, N.S., Langenau, D.M., Traver, D., Look, A.T., and Zon, L.I. (2004) The use of zebrafish to understand immunity. Immunity. 20(4):367-379.
Abstract
For decades immunologists have relied heavily on the mouse model for their experimental designs. With the realization of the important role innate immunity plays in orchestrating immune responses, invertebrates such as worms and flies have been added to the repertoire. Here, we discuss the advent of the zebrafish as a powerful vertebrate model organism that promises to positively impact immunologic research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping