PUBLICATION
Control of crystal size and lattice formation by starmaker in otolith biomineralization
- Authors
- Söllner, C., Burghammer, M., Busch-Nentwich, E., Berger, J., Schwarz, H., Riekel, C., and Nicolson, T.
- ID
- ZDB-PUB-031014-4
- Date
- 2003
- Source
- Science (New York, N.Y.) 302(5643): 282-286 (Journal)
- Registered Authors
- Busch-Nentwich, Elisabeth, Nicolson, Teresa, Söllner, Christian
- Keywords
- none
- MeSH Terms
-
- Molecular Sequence Data
- Animals
- Phenotype
- Calcification, Physiologic*
- Crystallization
- X-Ray Diffraction
- Oligonucleotides, Antisense
- Otolithic Membrane/chemistry
- Otolithic Membrane/growth & development
- Otolithic Membrane/physiology*
- Otolithic Membrane/ultrastructure
- Zebrafish/anatomy & histology
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/physiology*
- Crystallography, X-Ray
- Ear/embryology
- Ear/physiology
- Computational Biology
- Morphogenesis
- Gene Expression
- Amino Acid Sequence
- Hearing
- Hydrogen-Ion Concentration
- Calcium Carbonate/chemistry
- Postural Balance
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/physiology*
- Microscopy, Electron, Scanning
- PubMed
- 14551434 Full text @ Science
Citation
Söllner, C., Burghammer, M., Busch-Nentwich, E., Berger, J., Schwarz, H., Riekel, C., and Nicolson, T. (2003) Control of crystal size and lattice formation by starmaker in otolith biomineralization. Science (New York, N.Y.). 302(5643):282-286.
Abstract
The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping