PUBLICATION
Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis
- Authors
- Prouty, M.G., Correa, N.E., Barker, L.P., Jagadeeswaran, P., and Klose, K.E.
- ID
- ZDB-PUB-030908-11
- Date
- 2003
- Source
- FEMS microbiology letters 225(2): 177-182 (Journal)
- Registered Authors
- Jagadeeswaran, Pudur
- Keywords
- none
- MeSH Terms
-
- Animals
- Colony Count, Microbial
- Disease Models, Animal*
- Mycobacterium Infections, Nontuberculous/genetics
- Mycobacterium Infections, Nontuberculous/microbiology*
- Mycobacterium Infections, Nontuberculous/pathology*
- Mycobacterium marinum/growth & development
- Mycobacterium marinum/pathogenicity*
- Virulence
- Zebrafish/genetics
- Zebrafish/microbiology*
- PubMed
- 12951238 Full text @ FEMS Microbiol. Lett.
Citation
Prouty, M.G., Correa, N.E., Barker, L.P., Jagadeeswaran, P., and Klose, K.E. (2003) Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS microbiology letters. 225(2):177-182.
Abstract
We report here the development of a pathogenesis model utilizing Mycobacterium marinum infection of zebrafish (Danio rerio) for the study of mycobacterial disease. The zebrafish model mimics certain aspects of human tuberculosis, such as the formation of granuloma-like lesions and the ability to establish either an acute or a chronic infection based upon inoculum. This model allows the genetics of mycobacterial disease to be studied in both pathogen and host.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping