ZFIN ID: ZDB-PUB-030716-16
Cadherin expression in the inner ear of developing zebrafish
Novince, Z.M., Azodi, E., Marrs, J.A., Raymond, P.A., and Liu, Q.
Date: 2003
Source: Gene expression patterns : GEP   3(3): 337-339 (Journal)
Registered Authors: Liu, Qin, Marrs, James A., Raymond, Pamela
Keywords: none
MeSH Terms:
  • Animals
  • Cadherins/biosynthesis
  • Cadherins/genetics*
  • Ear, Inner/embryology
  • Ear, Inner/metabolism*
  • Gene Expression Profiling
  • In Situ Hybridization
  • RNA, Messenger/metabolism
  • Zebrafish/embryology
  • Zebrafish/metabolism*
PubMed: 12799081 Full text @ Gene Expr. Patterns
Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells.