ZFIN ID: ZDB-PUB-030304-1
The transformation of the model organism: a decade of developmental genetics
Anderson, K.V. and Ingham, P.W.
Date: 2003
Source: Nature Genetics   (Suppl.) 33: 285-293 (Review)
Registered Authors: Ingham, Philip
Keywords: none
MeSH Terms:
  • Animals
  • Cell Polarity
  • Developmental Biology/history
  • Developmental Biology/trends
  • Drosophila/genetics
  • Drosophila/growth & development
  • Feedback
  • Genetics/history
  • Genetics/trends
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Mice
  • Models, Genetic*
  • Signal Transduction
  • Zebrafish/genetics
  • Zebrafish/growth & development
PubMed: 12610538 Full text @ Nat. Genet.
The past decade has seen the development of powerful techniques to dissect the molecular processes that regulate development. New tools have been used to reveal the basis of cell polarity, morphogen gradients and regulation of signaling in developing animals. Cell biology and developmental biology have become closely intertwined, and many genes that had been thought of as regulators of general cell biological (housekeeping) functions have been shown to act as specific developmental regulators. Vertebrate developmental genetics is now flourishing, with forward and reverse genetics in both zebrafish and the mouse providing new dimensions to our understanding of development.