PUBLICATION

Zinc finger protein too few controls the development of monoaminergic neurons

Authors
Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A.
ID
ZDB-PUB-030116-6
Date
2003
Source
Nature Neuroscience   6(1): 28-33 (Journal)
Registered Authors
Hashimoto, Hisashi, Hibi, Masahiko, Levkowitz, Gil, Sirotkin, Howard, Talbot, William S., Zeller, Joerg
Keywords
none
MeSH Terms
  • Cell Differentiation/genetics*
  • Neurons/cytology
  • Neurons/metabolism*
  • Dopamine/metabolism
  • Brain/cytology
  • Brain/embryology*
  • Brain/metabolism
  • Apoptosis/genetics
  • Chromosome Mapping
  • Signal Transduction/genetics
  • Embryo, Nonmammalian
  • Stem Cells/cytology
  • Stem Cells/metabolism*
  • Zebrafish
  • Zinc Fingers/genetics
  • Gene Expression Regulation, Developmental/genetics
  • Female
  • Male
  • Serotonin/metabolism
  • Brain Tissue Transplantation
  • Carrier Proteins/genetics
  • Carrier Proteins/isolation & purification*
  • Zebrafish Proteins*
  • Repressor Proteins/genetics
  • Repressor Proteins/isolation & purification
  • Animals
  • Anti-Bacterial Agents/chemical synthesis*
  • Biogenic Monoamines/metabolism*
  • Peptides*
(all 29)
PubMed
12469125 Full text @ Nat. Neurosci.
Abstract
The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant-too few (tof)-that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Levkowitz, G., Zeller, J., Sirotkin, H.I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W.S., and Rosenthal, A. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nature Neuroscience. 6(1):28-33.