PUBLICATION
A neuropeptide FF-related gene is expressed selectively in neurons of the terminal nerve in Danio rerio
- Authors
- Oehlmann, V., Korte, H., Sterner, C., and Korsching, S.
- ID
- ZDB-PUB-020912-6
- Date
- 2002
- Source
- Mechanisms of Development 117(1-2): 357-361 (Journal)
- Registered Authors
- Korsching, Sigrun, Oehlmann, Verena D.
- Keywords
- brain stem; Danio rerio; diencephalon; dil; FMRFamide; gonadotropin releasing hormone; hypothalamus; in situ hybridization; neuropeptide FF; nucleus olfactoretinalis; olfactory placode; preoptic area; prolactin releasing peptide; RFamide; RFRP; salmon-type gonadotropin releasing; hormone; telencephalon; teleost
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary/genetics
- Gene Expression Regulation, Developmental
- Gonadotropin-Releasing Hormone/genetics
- In Situ Hybridization
- Molecular Sequence Data
- Nervous System/embryology
- Nervous System/growth & development
- Nervous System/metabolism
- Neurons/metabolism*
- Oligopeptides/genetics*
- Phylogeny
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish/growth & development*
- Zebrafish Proteins/genetics*
- PubMed
- 12204285 Full text @ Mech. Dev.
Citation
Oehlmann, V., Korte, H., Sterner, C., and Korsching, S. (2002) A neuropeptide FF-related gene is expressed selectively in neurons of the terminal nerve in Danio rerio. Mechanisms of Development. 117(1-2):357-361.
Abstract
RFamides constitute a large family of neuromodulatory peptides. We have cloned a zebrafish gene, which is presumably a homologue to the mammalian PQRF subfamily of RFamides, and named it zfPQRF for its species and subfamily allocation. We report that in contrast to its mammalian counterparts zfPQRF is expressed in the olfactory bulb and the nucleus olfactoretinalis in the telencephalon, but absent in more caudal regions, including hypothalamus, brain stem and spinal cord. zfPQRF-expressing neurons originate in the vicinity of the olfactory placode and populate the nuclei of the terminal nerve during later development, as demonstrated by co-expression of zebrafish salmon-type gonadotropin releasing hormone, which was found to exclusively label terminal nerve neurons.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping