ZFIN ID: ZDB-PUB-020807-24
From zebrafish to human: modular medical models
Shin, J.T. and Fishman, M.C.
Date: 2002
Source: Annual review of genomics and human genetics   3: 311-340 (Review)
Registered Authors: Fishman, Mark C., Shin, Jordan
Keywords: none
MeSH Terms:
  • Animals
  • Disease Models, Animal*
  • Genetic Diseases, Inborn/genetics*
  • Genetics, Medical*
  • Genome*
  • Genome, Human*
  • Humans
  • Models, Genetic
  • Mutation
  • Phenotype
  • Zebrafish/genetics*
PubMed: 12142362 Full text @ Annu. Rev. Genomics Hum. Genet.
Genetic screens in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio clarified the logic of metazoan development by revealing critical unitary steps and pathways to embryogenesis. Can genetic screens similarly organize medicine? We here examine human diseases that resemble mutations in Danio rerio, the zebrafish, the one vertebrate species for which large-scale genetic screens have been performed and extensively analyzed. Zebrafish mutations faithfully phenocopy many human disorders. Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics.