ZFIN ID: ZDB-PUB-020604-7
Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system
Liu, Q., Babb, S.G., Novince, Z.M., Doedens, A.L., Marrs, J., and Raymond, P.A.
Date: 2001
Source: Visual neuroscience   18(6): 923-933 (Journal)
Registered Authors: Clendenon, Sherry, Liu, Qin, Marrs, James A., Raymond, Pamela
Keywords: zebrafish; development; retina; cell adhesion molecules
MeSH Terms:
  • Animals
  • Cadherins/genetics*
  • Cadherins/metabolism
  • Embryo, Nonmammalian/metabolism*
  • Eye/embryology*
  • Eye/metabolism*
  • Fluorescent Antibody Technique, Indirect
  • Gene Expression
  • Gene Library
  • Immunoenzyme Techniques
  • In Situ Hybridization
  • RNA, Messenger/metabolism
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed: 12020083 Full text @ Vis. Neurosci.
Cadherins are homophilic cell adhesion molecules that control development of a variety of tissues and maintenance of adult structures . Although cadherins have been implicated in the development of the brain, including the visual system, in several vertebrate species, little is known of their role in zebrafish. In this study, we examined distribution of cadherin-2 (Cdh2, N-cadherin) in the visual system of developing and adult zebrafish using both immunocytochemical and in situ hybridization methods, and we compared Cdh2 distribution to that of the previously reported and closely related cadherin-4 (Cdh4, R-cadherin). As in other vertebrates, in zebrafish embryos Cdh2 was widely expressed in the early nervous system, but its expression became more restricted as development proceeded. Cdh4 was not detectable until later in development, at about the time when the first ganglion cells are generated. Cdh2 and Cdh4 were expressed in distinct regions of developing visual structures, including the lens. We hypothesize that the differential expression of these two cadherins in developing zebrafish visual structures reflects functionally different roles in the development of the vertebrate visual system.