ZFIN ID: ZDB-PUB-011214-11
Expression of receptor protein-tyrosine phosphatase alpha, sigma and LAR during development of the zebrafish embryo
van der Sar, A., Betist, M., de Fockert, J., Overvoorde, J., Zivkovic, D., and den Hertog, J.
Date: 2001
Source: Mechanisms of Development   109(2): 423-426 (Journal)
Registered Authors: de Fockert, Jaco, den Hertog, Jeroen, Jongejan-Zivkovic, Dana, Overvoorde, John
Keywords: protein-tyrosine phosphatase, expression, zebrafish, development, embryo, system, mouse, delta
MeSH Terms:
  • Animals
  • Blotting, Northern
  • Central Nervous System/embryology
  • Cloning, Molecular
  • In Situ Hybridization
  • Molecular Sequence Data
  • Nerve Tissue Proteins*
  • Oligonucleotides, Antisense/pharmacology
  • Protein Structure, Tertiary
  • Protein Tyrosine Phosphatases/biosynthesis*
  • Protein Tyrosine Phosphatases/genetics
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Receptor-Like Protein Tyrosine Phosphatases, Class 4
  • Receptors, Cell Surface/biosynthesis*
  • Receptors, Cell Surface/genetics
  • Spinal Cord/embryology
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins
PubMed: 11731262 Full text @ Mech. Dev.
Receptor protein-tyrosine phosphatases (RPTPs) are key players in Drosophila development. To study the role of RPTPs in vertebrate development, we have cloned zebrafish (zf) RPTPs, including RPTP alpha (RPTPalpha), RPTP sigma (RPTPsigma) and LAR. These three RPTPs are broadly transcribed in early development. At 24h post fertilisation (hpf), all three genes are expressed in the nervous system in partially overlapping patterns. At 3 days post fertilisation zf-RPTPalpha and zf-LAR show similar expression patterns in the central nervous system (CNS), the pharyngeal arches, the pectoral fins and the spinal cord. Interestingly, zf-LAR is uniquely expressed in the neuromast cells, whereas zf-RPTPsigma expression is confined to the central nervous system.