ZFIN ID: ZDB-PUB-011108-4
Identification and expression of zebrafish Iroquois homeobox gene irx1
Cheng, C.W., Hui, C.C., Strähle, U., and Cheng, S.H.
Date: 2001
Source: Development genes and evolution   211(8-9): 442-444 (Journal)
Registered Authors: Cheng, Shuk Han, Strähle, Uwe
Keywords: tectum; tegmentum; trigeminal ganglia; rhombomere; homeobox gene
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Brain/embryology
  • Brain/metabolism
  • Cloning, Molecular
  • Conserved Sequence
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins/chemistry
  • Homeodomain Proteins/genetics*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Transcription Factors/chemistry
  • Transcription Factors/genetics*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
PubMed: 11685579 Full text @ Dev. Genes Evol.
Iroquois homeoproteins are prepatterning factors that positively regulate proneural genes and control neurogenesis. We have identified a zebrafish Iroquois gene, irx1, which is highly homologous to Xenopus Xiro1, Gallus c-Irx1 and mouse Irx1. Expression of irx1 was initially detected at the bud stage. By 16 h post-fertilization (hpf), irx1 expression was exclusively limited to the prospective midbrain and hindbrain. By 24 hpf, irx1 expression was clearly detected in the acousticovestibual ganglia, tectum, tegmentum, cerebellum and rhombomere 1 but not in rhombomere 2 or mid-hindbrain boundary.