ZFIN Person: Cheng, Shuk Han

ZFIN ID: ZDB-PERS-980731-1

ZFIN ID: ZDB-PERS-980731-1

Cheng, Shuk Han

Email:	bhcheng@cityu.edu.hk
URL:
Affiliation:
Address:	City University of Hong Kong Tat Chee Avenue Kowloon, Hong Kong
Country:
Phone:	852-2788-9027
Fax:	852-2788-7406
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Chen, S., Jiao, Y., Pan, F., Guan, Z., Cheng, S.H., Sun, D. (2022) Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System. IEEE transactions on bio-medical engineering. 69(8):2524-2532

Xu, S., Xie, F., Tian, L., Fallah, S., Babaei, F., Manno, S.H., Manno Iii, F.A.M., Zhu, L., Wong, K.F., Liang, Y., Ramalingam, R., Sun, L., Wang, X., Plumb, R., Gethings, L., Lam, Y.W., Cheng, S.H. (2020) Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish. The Journal of endocrinology. 245(1):39-51

Liu, H., Li, X., Wei, T., Xu, S., Chen, S., Cheng, S.H., Sun, D. (2019) Precise Drug Delivery by Using PLGA-Based Microspheres and Optical Manipulators. IEEE Transactions on Nanobioscience. 19(2):192-202

Xu, S., Xie, F., Tian, L., Manno, S.H., Manno, F.A.M., Cheng, S.H. (2019) Prolonged neutrophil retention in the wound impairs zebrafish heart regeneration after cryoinjury. Fish & shellfish immunology. 94:447-454

Xu, S., Liu, C., Xie, F., Tian, L., Manno, S.H., Manno, F.A.M., Fallah, S., Pelster, B., Tse, G., Cheng, S.H. (2019) Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury. Fish & shellfish immunology. 89:117-126

Lin, X., Duan, X., Jacobs, C., Ullmann, J., Chan, C.Y., Chen, S., Cheng, S.H., Zhao, W.N., Poduri, A., Wang, X., Haggarty, S.J., Shi, P. (2018) High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology. Nature communications. 9:5142

Xu, S., Webb, S.E., Lau, T.C.K., Cheng, S.H. (2018) Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration. Scientific Reports. 8:7199

Li, L., Liu, C.C., Chen, X., Xu, S., Hernandez Cortes-Manno, S., Cheng, S.H. (2017) Mechanistic Study of Bakuchiol-Induced Anti-breast Cancer Stem Cell and in Vivo Anti-metastasis Effects.. Frontiers in pharmacology. 8:746

Ng, C.Y., Cheng, S.H., Yu, K.N. (2017) Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos. International Journal of Molecular Sciences. 18(2)

Kong, E.Y., Cheng, S.H., Yu, K.N. (2016) Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation. International Journal of Molecular Sciences. 17(12)

Babaei, F., Hong, T.L., Yeung, K., Cheng, S.H., Lam, Y.W. (2016) Contrast-Enhanced X-ray Micro-Computed Tomography as a Versatile Method for Anatomical Studies of Adult Zebrafish. Zebrafish. 13(4):310-6

Ng, C.Y., Pereira, S., Cheng, S.H., Adam-Guillermin, C., Garnier-Laplace, J., Yu, K.N. (2016) Combined effects of alpha particles and depleted uranium on Zebrafish (Danio rerio) embryos. Journal of radiation research. 57(4):343-55

Kong, E.Y., Cheng, S.H., Yu, K.N. (2016) Biphasic and triphasic dose responses in zebrafish embryos to low-dose 150 kV X-rays with different levels of hardness. Journal of radiation research. 57(4):363-9

Ng, C.Y., Kong, E.Y., Kobayashi, A., Suya, N., Uchihori, Y., Cheng, S.H., Konishi, T., Yu, K.N. (2016) Non-induction of radioadaptive response in zebrafish embryos by neutrons. Journal of radiation research. 57(3):210-9

Ng, C.Y., Cheng, S.H., Yu, K.N. (2016) Hormetic effect induced by depleted uranium in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 175:184-191

Li, L., Chen, X., Liu, C.C., Lee, L.S., Man, C., Cheng, S.H. (2016) Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis. Frontiers in pharmacology. 7:128

Li, V.W., Tsui, M.P., Chen, X., Hui, M.N., Jin, L., Lam, R.H., Yu, R.M., Murphy, M.B., Cheng, J., Lam, P.K., Cheng, S.H. (2016) Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos. Environmental science and pollution research international. 23(9):8275-85

Liu, C.C., Li, L., Lam, Y.W., Siu, C.W., Cheng, S.H. (2016) Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation. Scientific Reports. 6:25073

Lin, X., Li, V.W., Chen, S., Chan, C.Y., Cheng, S.H., Shi, P. (2016) Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish. Biomicrofluidics. 10:024123

Tang, T.S., Leung, K., Louie, M., Liu, H., Cheng, S.H., Lo, K.K. (2015) Phosphorescent biscyclometallated iridium(iii) ethylenediamine complexes functionalised with polar ester or carboxylate groups as bioimaging and visualisation reagents. Dalton transactions (Cambridge, England : 2003). 44(11):4945-56

Lin, X., Wang, S., Yu, X., Liu, Z., Wang, F., Li, W.T., Cheng, S.H., Dai, Q., Shi, P. (2015) High-throughput mapping of brain-wide activity in awake and drug-responsive vertebrates. Lab on a Chip. 15(3):680-9

Chen, X., Xu, S., Tan, T., Lee, S.T., Cheng, S.H., Lee, F.W., Xu, S.J., Ho, K.C. (2014) Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. International Journal of Environmental Research and Public Health. 11:3156-68

Li, S.P., Lau, C.T., Louie, M.W., Lam, Y.W., Cheng, S.H., and Lo, K.K. (2013) Mitochondria-targeting cyclometalated iridium(III)-PEG complexes with tunable photodynamic activity. Biomaterials. 34(30):7519-32

Choi, V.W., Ng, C.Y., Kobayashi, A., Konishi, T., Suya, N., Ishikawa, T., Cheng, S.H., and Yu, K.N. (2013) Bystander Effect between Zebrafish Embryos in Vivo Induced by High-Dose X-rays. Environmental science & technology. 47(12):6368-76

Shi, Y., Liu, X., Zhu, P., Li, J., Sham, K.W., Cheng, S.H., Li, S., Zhang, Y., Cheng, C.H., and Lin, H. (2013) G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis. Biochemical and Biophysical Research Communications. 435(1):21-7

Babaei, F., Ramalingam, R., Tavendale, A., Liang, Y., Yan, L.S., Ajuh, P., Cheng, S.H., and Lam, Y.W. (2013) Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish. Journal of Proteome Research. 12(4):1580-90

Choi, V.W., Ng, C.Y., Kong, M.K., Cheng, S.H., and Yu, K.N. (2013) Adaptive response to ionising radiation induced by cadmium in zebrafish embryos. Journal of radiological protection : official journal of the Society for Radiological Protection. 33(1):101-112

Ng, C.Y., Choi, V.W., Lam, A.C., Cheng, S.H., and Yu, K.N. (2013) The multiple stressor effect in zebrafish embryos from simultaneous exposure to ionising radiation and cadmium. Journal of radiological protection : official journal of the Society for Radiological Protection. 33(1):113-121

Choi, V.W., Konishi, T., Oikawa, M., Cheng, S.H., and Yu, K.N. (2013) The threshold number of protons to induce an adaptive response in zebrafish embryos. Journal of radiological protection : official journal of the Society for Radiological Protection. 33(1):91-100

Choi, A.W., Louie, M.W., Li, S.P., Liu, H.W., Chan, B.T., Lam, T.C., Lin, A.C., Cheng, S.H., and Lo, K.K. (2012) Emissive Behavior, Cytotoxic Activity, Cellular Uptake, and PEGylation Properties of New Luminescent Rhenium(I) Polypyridine Poly(ethylene glycol) Complexes. Inorganic chemistry. 51(24):13289-13302

Choi, V.W., Cheung, A.L., Cheng, S.H., and Yu, P.K. (2012) Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos. Environmental science & technology. 46(21):11678-11683

Yu, K.N., Tung, M.M., Choi, V.W., and Cheng, S.H. (2012) Alpha radiation exposure decreases apoptotic cells in zebrafish embryos subsequently exposed to the chemical stressor, Cd. Environmental science and pollution research international. 19(9):3831-3839

Finn, J., Hui, M., Li, V., Lorenzi, V., de la Paz, N., Cheng, S.H., Lai-Chan, L., and Schlenk, D. (2012) Effects of propranolol on heart rate and development in Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 122-123C:214-221

Yu, R.M., Chu, D.L., Tan, T.F., Li, V.W., Chan, A.K., Giesy, J.P., Cheng, S.H., Wu, R., and Kong, R. (2012) Leptin-mediated modulation of steroidogenic gene expression in hypoxic zebrafish embryos: Implications for the disruption of sex steroids. Environmental science & technology. 46(16):9112-9119

Choi, V.W., Wong, M.Y., Cheng, S.H., and Yu, K.N. (2012) Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 70(7):1075-1079

Tse, H.Y., Hui, M.N., Li, L., Lee, S.M., Leung, A.Y., and Cheng, S.H. (2012) Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. Journal of ethnopharmacology. 139(2):447-53

Choi, V.W., Ng, C.Y., Cheng, S.H., and Yu, P.K. (2012) Alpha-particle irradiated zebrafish embryos rescued by bystander unirradiated zebrafish embryos. Environmental science & technology. 46(1):226-231

Cheng, J., and Cheng, S.H. (2012) Influence of carbon nanotube length on toxicity to zebrafish embryos. International Journal of Nanomedicine. 7:3731-3739

Choi, V.W., Yum, E.H., Konishi, T., Oikawa, M., Cheng, S.H., and Yu, K.N. (2012) Triphasic Low-dose Response in Zebrafish Embryos Irradiated by Microbeam Protons. Journal of radiation research. 53(3):475-481

Lo, K.H., Hui, M.N., Yu, R.M., Wu, R.S., and Cheng, S.H. (2011) Hypoxia Impairs Primordial Germ Cell Migration in Zebrafish (Danio rerio) Embryos. PLoS One. 6(9):e24540

Cheng, J., Gu, Y.J., Wang, Y., Cheng, S.H., and Wong, W.T. (2011) Nanotherapeutics in angiogenesis: synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos. International Journal of Nanomedicine. 6:2007-2021

Choi, V.W., Cheng, S.H., and Yu, K.N. (2010) Radioadaptive Response Induced by Alpha-Particle-Induced Stress Communicated in Vivo between Zebrafish Embryos. Environmental science & technology. 44(23):8829-8834

Tan, Y., Sun, D., Huang, W., and Cheng, S.H. (2010) Characterizing Mechanical Properties of Biological Cells by Microinjection. IEEE Transactions on Nanobioscience. 9(3):171-180

Yum, E.H., Li, V.W., Choi, V.W., Cheng, S.H., and Yu, K.N. (2010) Effects of alpha particles on zebrafish embryos. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 68(4-5):714-717

Alex, D., Leong, E.C., Zhang, Z.J., Yan, G.T., Cheng, S.H., Leong, C.W., Li, Z.H., Lam, K.H., Chan, S.W., and Lee, S.M. (2010) Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. Journal of cellular biochemistry. 109(2):339-346

Choi, V.W., Konishi, T., Oikawa, M., Iso, H., Cheng, S.H., and Yu, K.N. (2010) Adaptive Response in Zebrafish Embryos Induced Using Microbeam Protons as Priming Dose and X-ray Photons as Challenging Dose. Journal of radiation research. 51(6):657-664

Steele, S.L., Lo, K.H., Li, V.W., Cheng, S.H., Ekker, M., and Perry, S.F. (2009) Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac {beta}-adrenergic sensitivity in larval zebrafish Danio rerio. American journal of physiology. Regulatory, integrative and comparative physiology. 297(2):R412-R420

Huang, X., Hui, M.N., Liu, Y., Yuen, D.S., Zhang, Y., Chan, W.Y., Lin, H.R., Cheng, S.H., and Cheng, C.H. (2009) Discovery of a novel prolactin in non-mammalian vertebrates: evolutionary perspectives and its involvement in teleost retina development. PLoS One. 4(7):e6163

Chen, X., Li, L., Wong, C.K., and Cheng, S.H. (2009) Rapid adaptation of molecular resources from zebrafish and medaka to develop an estuarine/marine model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 149(4):647-655

Cheng, J., Chan, C.M., Veca, L.M., On, W.L., Chan, P.K., Qu, L., Sun, Y.P., and Cheng, S.H. (2009) Acute and long-term effects after single loading of functionalized multi-walled carbon nanotubes into zebrafish (Danio rerio). Toxicology and applied pharmacology. 235(2):216-225

Chan, P.K., Lin, C.C., and Cheng, S.H. (2009) Noninvasive technique for measurement of heartbeat regularity in zebrafish (Danio rerio) embryos. BMC Biotechnology. 9:11

Chow, E.S., Hui, M.N., Cheng, C.W., and Cheng, S.H. (2009) Cadmium affects retinogenesis during zebrafish embryonic development. Toxicology and applied pharmacology. 235(1):68-76

Tan, Y., Sun, D., Huang, W., and Cheng, S.H. (2008) Mechanical modeling of biological cells in microinjection. IEEE Transactions on Nanobioscience. 7(4):257-266

Tse, H.Y., Li, V.W., Hui, M.N., Chan, P.K., and Cheng, S.H. (2008) Data Mining for Chinese Materia Medica and Pharmacological Research. Journal of Biomolecular Screening. 13(5):390-395

Chow, E.S., Hui, M.N., Lin, C.C., and Cheng, S.H. (2008) Cadmium inhibits neurogenesis in zebrafish embryonic brain development. Aquatic toxicology (Amsterdam, Netherlands). 87(3):157-169

Cheng, C.W., Yan, C.H., Choy, S.W., Hui, M.N., Hui, C.C., and Cheng, S.H. (2007) Zebrafish homologue irx1a is required for the differentiation of serotonergic neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(9):2661-2667

Lin, C.C., Hui, M.N., and Cheng, S.H. (2007) Toxicity and cardiac effects of carbaryl in early developing zebrafish (Danio rerio) embryos. Toxicology and applied pharmacology. 222(2):159-168

Cheng, J., Flahaut, E., and Cheng, S.H. (2007) Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos. Environmental toxicology and chemistry. 26(4):708-716

Yu, R.M., Lin, C.C., Chan, P.K., Chow, E.S., Murphy, M.B., Chan, B.P., Muller, F., Strähle, U., and Cheng, S.H. (2006) Four-dimensional Imaging and Quantification of Gene Expression in Early Developing Zebrafish (Danio rerio) Embryos. Toxicological sciences : an official journal of the Society of Toxicology. 90(2):529-538

Cheng, C.W., Yan, C.H., Hui, C.C., Strähle, U., and Cheng, S.H. (2006) The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina. Mechanisms of Development. 123(3):252-263

Feng, J., Ip, H.H., Cheng, S.H., and Chan, P.K. (2004) A relational-tubular (ReTu) deformable model for vasculature quantification of zebrafish embryo from microangiography image series. Comput. Med. Imaging Graph.. 28(6):333-344

Hen Chow, E.S. and Cheng, S.H. (2003) Cadmium affects muscle type development and axon growth in zebrafish embryonic somitogenesis. Toxicological sciences : an official journal of the Society of Toxicology. 73(1):149-159

Chan, P.K. and Cheng, S.H. (2003) Fractal analysis of vascular complexity in cadmium-treated zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 63(1):83-87

Chan, P.-K. and Cheng, S.-H. (2003) Cadmium-induced ectopic apoptosis in zebrafish embryos. Archives of toxicology. 77(2):69-79

Yan, C.H.M. and Cheng, S.H. (2002) Sonic hedgehog induces ectopic expression of zebrafish iroquois gene (ziro1b) during neural development. American journal of human genetics. 71(4):318

Cheng, C.W., Hui, C.C., Strähle, U., and Cheng, S.H. (2001) Identification and expression of zebrafish Iroquois homeobox gene irx1. Development genes and evolution. 211(8-9):442-444

Cheng, S.H., Chan, P.K., and Wu, R.S.S. (2001) The use of microangiography in detecting aberrant vasculature in zebrafish embryos exposed to cadmium. Aquatic toxicology (Amsterdam, Netherlands). 52(1):61-71

Cheng, S.H., Wai, A.W.K., So, C.H., and Wu, R.S.S. (2000) Cellular and molecular basis of cadmium-induced deformities in zebrafish embryos. Environmental toxicology and chemistry. 19(12):3024-3031

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