PUBLICATION
Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis
- Authors
- Park, H.-C., Hong, S.-K., Kim, H.-S., Kim, S.-H., Yoon, E.-J., Kim, C.-H., Miki, N., and Huh, T.-L.
- ID
- ZDB-PUB-000125-9
- Date
- 2000
- Source
- Neuroscience letters 279(2): 81-84 (Journal)
- Registered Authors
- Hong, Sung-Kook, Huh, Tae-Lin, Kim, Cheol-Hee, Kim, Hyung-Seok, Kim, Seok-Hyung, Miki, Naomasa, Park, Hae-Chul
- Keywords
- zebrafish; HuA; HuG; HuD; HuC; neural plate; neuronal differentiation; neuronal determination
- MeSH Terms
-
- Nerve Tissue Proteins/chemistry
- Nerve Tissue Proteins/genetics*
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Amino Acid Sequence
- ELAV-Like Protein 3
- Sequence Alignment
- Animals
- Brain/embryology*
- ELAV Proteins
- Neurons/physiology*
- RNA-Binding Proteins/chemistry
- RNA-Binding Proteins/genetics*
- Spinal Cord/embryology*
- Zebrafish/embryology*
- Zebrafish/genetics*
- Antigens, Surface/chemistry
- Antigens, Surface/genetics*
- Zebrafish Proteins*
- Gene Expression Regulation, Developmental*
- PubMed
- 10674626 Full text @ Neurosci. Lett.
Citation
Park, H.-C., Hong, S.-K., Kim, H.-S., Kim, S.-H., Yoon, E.-J., Kim, C.-H., Miki, N., and Huh, T.-L. (2000) Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neuroscience letters. 279(2):81-84.
Abstract
The present communication reports the isolation and characterization of three new zebrafish elav/Hu (Kim, C.-H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo,
S.-Y., Huh, T.-L. and Miki, N., Zebrafish elav/HuC homologue as a very early neuronal marker. Neurosci. Lett., 216 (1996) 109¯112) homologues, HuA,
HuD and HuG. While HuA and HuG showed weak and ubiquitous expressions, HuD, as well as HuC, were specifically expressed in the neuronal cells. The first
expression of HuD was detectable of the 10-somite stage, that is, several hours later than HuC. After 24 h of embryonic development, although HuD and HuC
expressions overlapped overall, the cells expressing HuD were restricted to subsets of the HuC-positive neuronal cells in the brain and spinal cord. These
differentially regulated spatial and temporal expression patterns implied distinct roles for HuC and HuD in neuronal determination and neuronal differentiation, respectively.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping