ZFIN ID: ZDB-PUB-000118-15
Developmental regulation of Tbx5 in zebrafish embryogenesis
Begemann, G. and Ingham, P.W.
Date: 2000
Source: Mechanisms of Development   90(2): 299-304 (Journal)
Registered Authors: Begemann, Gerrit, Ingham, Philip
Keywords: T-box; Tbx5; Holt-Oram syndrome; lateral plate mesoderm; heart; pectoral fin; apical fold; limb development; retina; zebrafish
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • Gene Expression Regulation, Developmental*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • T-Box Domain Proteins/genetics*
  • Tissue Distribution
  • Zebrafish
PubMed: 10640716 Full text @ Mech. Dev.
T-box (tbx) genes constitute a large family of transcriptional regulators involved in developmental patterning processes. In tetrapods, tbx5 has been implicated in specifying forelimb type identity. Here, we report the cloning of the zebrafish tbx5.1 gene and characterise its expression during zebrafish embryogenesis and early larval development of wild type and mutant embryos that affect pectoral fin patterning. tbx5.1 is expressed during development of the heart, the pectoral fins and the eye. Notably, its expression in the lateral plate mesoderm defines a single and continuous region of heart and pectoral fin precursor cells, and constitutes the earliest specific marker for pectoral fin development in the zebrafish.