PUBLICATION
Sequence and embryonic expression of deltaC in the zebrafish
- Authors
- Smithers, L., Haddon, C., Jiang, Y.J., and Lewis, J.
- ID
- ZDB-PUB-000111-4
- Date
- 2000
- Source
- Mechanisms of Development 90(1): 119-123 (Journal)
- Registered Authors
- Haddon, Catherine, Jiang, Yun-Jin, Lewis, Julian
- Keywords
- zebrafish; Delta; Notch; X-Delta-2; deltaA, deltaB, deltaC, deltaD; notch1a; pax2.1; vegr-2; germ ring; tailbud; somites; neural tube; ear, retina; lateral line; cranial ganglia; notochord; aorta; endothelium; pronephros; epidermis
- MeSH Terms
-
- Animals
- DNA, Complementary/genetics
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/physiology
- Gene Expression Regulation, Developmental*
- Homeodomain Proteins/biosynthesis
- Homeodomain Proteins/genetics
- In Situ Hybridization
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins/biosynthesis
- Membrane Proteins/genetics*
- Zebrafish/embryology*
- Zebrafish/physiology
- PubMed
- 10585570 Full text @ Mech. Dev.
Citation
Smithers, L., Haddon, C., Jiang, Y.J., and Lewis, J. (2000) Sequence and embryonic expression of deltaC in the zebrafish. Mechanisms of Development. 90(1):119-123.
Abstract
Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We
report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC is not expressed in the majority of nascent primary neurons; but it is strongly expressed in the early retina, where it precedes other delta genes. It is also expressed in cranial ganglia, in sensory epithelia including ear and lateral line, and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly; it is seen subsequently in the tail bud, in stripes in the presomitic mesoderm and in the posterior half of each somite. There is expression also in notochord, blood vessels and pronephros.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping