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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-331
Lewis, Julian (Deceased)
Email:
URL:
Affiliation: Vertebrate Development Laboratory
Address: Cancer Research UK P.O. Box 123 44 Lincoln's Inn Fields London, WC2A 3PX United Kingdom
Country: United Kingdom
Phone: 44-207-269-3510
Fax: 44-207-269-3417
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Jenkins, R.P., Hanisch, A., Soza-Ried, C., Sahai, E., Lewis, J. (2015) Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling. PLoS Computational Biology. 11:e1004459
Soza-Ried, C., Oztürk, E., Ish-Horowicz, D., Lewis, J. (2014) Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock. Development (Cambridge, England). 141:1780-8
Hanisch, A., Holder, M.V., Choorapoikayil, S., Gajewski, M., Ozbudak, E.M., and Lewis, J. (2013) The elongation rate of RNA polymerase II in zebrafish and its significance in the somite segmentation clock. Development (Cambridge, England). 140(2):444-453
Fior, R., Maxwell, A.A., Ma, T.P., Vezzaro, A., Moens, C.B., Amacher, S.L., Lewis, J., and Saúde, L. (2012) The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development (Cambridge, England). 139(24):4656-4665
Wright, G.J., Giudicelli, F., Soza-Ried, C., Hanisch, A., Ariza-McNaughton, L., and Lewis, J. (2011) DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock. Development (Cambridge, England). 138:2947-2956
Collins, R.T., Linker, C., and Lewis, J. (2010) MAZe: a tool for mosaic analysis of gene function in zebrafish. Nature Methods. 7(3):219-223
Gomez, C., Ozbudak, E.M., Wunderlich, J., Baumann, D., Lewis, J., and Pourquié, O. (2008) Control of segment number in vertebrate embryos. Nature. 454(7202):335-339
Ozbudak, E.M., and Lewis, J. (2008) Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries. PLoS Genetics. 4(2):e15
Lewis, J., and Ozbudak, E.M. (2007) Deciphering the somite segmentation clock: beyond mutants and morphants. Developmental dynamics : an official publication of the American Association of Anatomists. 236(6):1410-1415
Giudicelli, F., Ozbudak, E.M., Wright, G.J., and Lewis, J. (2007) Setting the Tempo in Development: An Investigation of the Zebrafish Somite Clock Mechanism. PLoS Biology. 5(6):e150
Leslie, J.D., Ariza-McNaughton, L., Bermange, A.L., McAdow, R., Johnson, S.L., and Lewis, J. (2007) Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development (Cambridge, England). 134(5):839-844
Julich, D., Hwee, Lim C., Round, J., Nicolaije, C., Schroeder, J., Davies, A., Geisler, R., Lewis, J., Jiang, Y.J., Holley, S.A., Tübingen 2000 Screen Consortium. (2005) beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation. Developmental Biology. 286(2):391-404
Crosnier, C., Vargesson, N., Gschmeissner, S., Ariza-McNaughton, L., Morrison, A., and Lewis, J. (2005) Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development (Cambridge, England). 132(5):1093-1104
Qiu, X., Xu, H., Haddon, C., Lewis, J., and Jiang, Y.J. (2004) Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe. Developmental dynamics : an official publication of the American Association of Anatomists. 231(3):621-630
Wright, G.J., Leslie, J.D., Ariza-McNaughton, L., and Lewis, J. (2004) Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Development (Cambridge, England). 131(22):5659-5669
Giudicelli, F., and Lewis, J. (2004) The vertebrate segmentation clock. Current opinion in genetics & development. 14(4):407-414
Lewis, J.L., Bonner, J., Modrell, M., Ragland, J.W., Moon, R.T., Dorsky, R.I., and Raible, D.W. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development (Cambridge, England). 131(6):1299-1308
Lewis, J. (2003) Autoinhibition with transcriptional delay. A simple mechanism for the zebrafish somitogenesis oscillator. Current biology : CB. 13(16):1398-1408
Itoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G.J., Ariza-McNaughton, L., Weissman, A.M., Lewis, J., Chandrasekharappa, S.C., and Chitnis, A.B. (2003) Mind Bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by Delta. Developmental Cell. 4(1):67-82
Davis, J.M., Clay, H., Lewis, J.L., Ghori, N., Herbomel, P., and Ramakrishnan, L. (2002) Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity. 17(6):693-702
Jiang, Y.-J. and Lewis, J. (2001) Notch as a synchroniser in somite segmentation. In Proceedings of the NATO Advanced Research Workshop on The Origin and Fate of Somites, E. J. Sanders, J. W. Lash and C. P. Ordahl, eds., Series I - Life and Behavioural Sciences, Amsterdam: IOS Press. 329:71-79
Jiang, Y.J., Aerne, B.L., Smithers, L., Haddon, C., Ish-Horowicz, D., and Lewis, J. (2000) Notch signalling and the synchronization of the somite segmentation clock. Nature. 408(6811):475-479
Smithers, L., Haddon, C., Jiang, Y.J., and Lewis, J. (2000) Sequence and embryonic expression of deltaC in the zebrafish. Mechanisms of Development. 90(1):119-123
Haddon, C., Mowbray, C., Whitfield, T., Jones, D., Gschmeissner, S., and Lewis, J. (1999) Hair cells without supporting cells: further studies in the ear of the zebrafish mind bomb mutant. Journal of neurocytology. 28(10-11):837-850
Jiang, Y.-J., Smithers, L., and Lewis, J. (1998) Vertebrate segmentation: The clock is linked to Notch signalling. Current biology : CB. 8(24):R868-R871
Haddon, C., Jiang, Y.-J., Smithers, L., and Lewis, J. (1998) Delta-Notch signaling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant. Development (Cambridge, England). 125:4637-4644
Haddon, C., Smithers, L., Schneider-Maunoury, S., Coche, T., Henrique, D. and Lewis, J. (1998) Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis. Development (Cambridge, England). 125:359-370
Whitfield, T., Haddon, C., and Lewis, J. (1997) Intercellular signals and cell-fate choices in the developing inner ear: origins of global and of fine-grained pattern. Seminars in cell & developmental biology. 8(3):239-247
Haddon, C. and Lewis, J. (1996) Early ear development in the embryo of the zebrafish, Danio rerio. The Journal of comparative neurology. 365:113-128

NON-ZEBRAFISH PUBLICATIONS