Morpholino

MO1-dre-mir-21-2

ID
ZDB-MRPHLNO-130806-1
Name
MO1-dre-mir-21-2
Previous Names
  • dremir-21-2 MO (1)
  • MO1-mir21-2
  • multi-blocker (1)
Target
Sequence
5' - ACTCAAAGCCAACACCAGTCTGATAAGCTAC - 3'
ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
This is a multi-blocker morpholino that targets both Drosha and Dicer processing sites in pre-mir21-2.
Genome Resources
None
Target Location
Genomic Features
No data available
Expression
Gene expression in Wild Types + MO1-dre-mir-21-2
Expressed Gene Anatomy Figures
bmp4 Fig. 2 with image from Kolpa et al., 2013
has2 Fig. 2 with image from Kolpa et al., 2013
notch1b Fig. 2 with image from Kolpa et al., 2013
nppa Fig. 2 with image from Kolpa et al., 2013
pdcd4b Fig. S4 with image from Kolpa et al., 2013
spp1 Fig. 2 with image from Kolpa et al., 2013
tbx2b Fig. 2 with image from Kolpa et al., 2013
vcana Fig. 2 with image from Kolpa et al., 2013
Phenotype
Phenotype resulting from MO1-dre-mir-21-2
Phenotype Fish Figures
atrioventricular ring immature, abnormal TL + MO1-dre-mir-21-2 Fig. 1 with image from Kolpa et al., 2013
atrioventricular valve development arrested, abnormal TL + MO1-dre-mir-21-2 Fig. 1 with image from Kolpa et al., 2013
heart looping disrupted, abnormal TL + MO1-dre-mir-21-2 Fig. 1 with image from Kolpa et al., 2013
pericardium edematous, abnormal TL + MO1-dre-mir-21-2 Fig. 1 with image from Kolpa et al., 2013
Phenotype of all Fish created by or utilizing MO1-dre-mir-21-2
Phenotype Fish Conditions Figures
atrioventricular valve development disrupted, abnormal AB + MO1-dre-mir-21-2 + MO3-dre-mir-21-2 standard conditions Fig. 1 with image from Wu et al., 2017
whole organism pcbp2 expression decreased amount, abnormal AB + MO1-dre-mir-21-2 + MO3-dre-mir-21-2 standard conditions Fig. 5 from Wu et al., 2017
whole organism tpm1 expression decreased amount, abnormal AB + MO1-dre-mir-21-2 + MO3-dre-mir-21-2 standard conditions Fig. 5 from Wu et al., 2017
whole organism nanog expression decreased amount, abnormal AB + MO1-dre-mir-21-2 + MO3-dre-mir-21-2 standard conditions Fig. 5 from Wu et al., 2017
whole organism Ab1-kat7 labeling decreased amount, abnormal AB + MO1-dre-mir-21-2 + MO3-dre-mir-21-2 standard conditions Fig. 5 from Wu et al., 2017
atrioventricular ring immature, abnormal TL + MO1-dre-mir-21-2 standard conditions Fig. 1 with image from Kolpa et al., 2013
atrioventricular valve development arrested, abnormal TL + MO1-dre-mir-21-2 standard conditions Fig. 1 with image from Kolpa et al., 2013
heart looping disrupted, abnormal TL + MO1-dre-mir-21-2 standard conditions Fig. 1 with image from Kolpa et al., 2013
pericardium edematous, abnormal TL + MO1-dre-mir-21-2 standard conditions Fig. 1 with image from Kolpa et al., 2013
heart decreased width, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4 from Banjo et al., 2013
atrioventricular canal has fewer parts of type endocardium cell, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. S3 from Banjo et al., 2013
blood cell accumulation yolk anatomical surface, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4 from Banjo et al., 2013
heart looping arrested, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4 from Banjo et al., 2013
hindbrain hypoplastic, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4 from Banjo et al., 2013
blood circulation decreased process quality, abnormal WT + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4 from Banjo et al., 2013
endocardial cushion aplastic, abnormal y1Tg + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4,  Fig. 6 from Banjo et al., 2013
atrioventricular canal cell population proliferation decreased process quality, abnormal y1Tg + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. S5 from Banjo et al., 2013
heart valve development disrupted, abnormal y1Tg + MO1-dre-mir-21-1 + MO1-dre-mir-21-2 standard conditions Fig. 4,  Fig. 6 from Banjo et al., 2013
Citations
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