ZFIN Morpholino: MO1-dio3b

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-dio3b

Expressed Gene	Anatomy	Figures
aldh1a2	periocular mesenchyme pharyngeal arch retina dorsal region whole organism (all 4)	Fig. 4 from Bohnsack et al., 2013
arr3a	retinal cone cell retinal photoreceptor layer green sensitive photoreceptor cell	Fig. 6 from Houbrechts et al., 2016
cyp26c1	hindbrain otic vesicle retina whole organism (all 4)	Fig. 4 from Bohnsack et al., 2013
foxa2	swim bladder bud	Fig. 5 from Heijlen et al., 2014
opn1sw1	retinal cone cell retinal photoreceptor layer UV sensitive photoreceptor cell UV sensitive photoreceptor cell photoreceptor outer segment	Fig. 6 from Houbrechts et al., 2016

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Phenotype

Phenotype resulting from MO1-dio3b

Phenotype	Fish	Figures
embryo development delayed, abnormal	WIK + MO1-dio3b	Fig. 3 from Heijlen et al., 2014
eye decreased area, abnormal	WIK + MO1-dio3b	Fig. 4 from Houbrechts et al., 2016
eye decreased size, abnormal	WIK + MO1-dio3b	Fig. 3 from Heijlen et al., 2014
hatching disrupted, abnormal	WIK + MO1-dio3b	Fig. 8, text only from Heijlen et al., 2014
hindbrain cyp26c1 expression increased amount, abnormal	WT + MO1-dio3b	Fig. 4 from Bohnsack et al., 2013

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Phenotype of all Fish created by or utilizing MO1-dio3b

Phenotype	Fish	Conditions	Figures
eye decreased area, abnormal	WIK + MO1-dio3b	standard conditions	Fig. 4 from Houbrechts et al., 2016
eye decreased size, abnormal	WIK + MO1-dio3b	standard conditions	Fig. 3 from Heijlen et al., 2014
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer blue sensitive photoreceptor cell, abnormal	WIK + MO1-dio3b	standard conditions	Fig. 6 , Fig. T4 from Houbrechts et al., 2016
retinal photoreceptor layer has fewer parts of type retinal photoreceptor layer red sensitive photoreceptor cell, abnormal	WIK + MO1-dio3b	standard conditions	Fig. 6 , Fig. T4 from Houbrechts et al., 2016
retinal neural layer disorganized, abnormal	WIK + MO1-dio3b	standard conditions	Fig. 5 from Houbrechts et al., 2016

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Citations

Include unpublished citations

van der Spek, A.H., Jim, K.K., Karaczyn, A., van Beeren, H.C., Ackermans, M.T., Darras, V.M., Vandenbroucke-Grauls, C.M.J.E., Hernandez, A., Brouwer, M.C., Fliers, E., van de Beek, D., Boelen, A. (2017) The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species. Endocrinology. 159(2):826-835
Houbrechts, A.M., Vergauwen, L., Bagci, E., Van Houcke, J., Heijlen, M., Kulemeka, B., Hyde, D.R., Knapen, D., Darras, V.M. (2016) Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function. Molecular and Cellular Endocrinology. 424:81-93
Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285
Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559
Bohnsack, B.L., and Kahana, A. (2013) Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Developmental Biology. 373(2):300-309
Heijlen, M., Houbrechts, A.M., and Darras, V.M. (2013) Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development. General and comparative endocrinology. 188:289-96

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