ZFIN Morpholino: MO1-ocrl

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ocrl

Expressed Gene	Anatomy	Figures
egr2b	rhombomere 3 rhombomere 5	Fig. S7 from Ramirez et al., 2012
hoxb1a	rhombomere 4	Fig. S7 from Ramirez et al., 2012
ocrl	whole organism	Fig. 3 from Ramirez et al., 2012
pax2a	midbrain hindbrain boundary optic stalk otic vesicle	Fig. S7 from Ramirez et al., 2012

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Phenotype

Phenotype resulting from MO1-ocrl

Phenotype	Fish	Figures
brain decreased size, abnormal	WT + MO1-ocrl	Fig. 6, Fig. S7 from Ramirez et al., 2012
eye decreased pigmentation, abnormal	WT + MO1-ocrl	Fig. 6 from Ramirez et al., 2012
eye decreased size, abnormal	WT + MO1-ocrl	Fig. 6 from Ramirez et al., 2012
midbrain hindbrain boundary morphology, abnormal	WT + MO1-ocrl	Fig. 6 from Ramirez et al., 2012
pinocytosis decreased efficacy, abnormal	WT + MO1-ocrl	Fig. 3. from Ates et al., 2020

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Phenotype of all Fish created by or utilizing MO1-ocrl

Phenotype	Fish	Conditions	Figures
pronephros decreased functionality, abnormal	AB + MO1-ocrl	control	Fig. 5 from Oltrabella et al., 2021
pronephric duct cilium decreased amount, abnormal	AB + MO1-ocrl	standard conditions	Fig. 5 from Oltrabella et al., 2015
pronephros renal absorption decreased process quality, abnormal	AB + MO1-ocrl	standard conditions	Fig. 1 from Oltrabella et al., 2015
pronephric proximal convoluted tubule endocytosis decreased process quality, abnormal	AB + MO1-ocrl	control	Fig. 5 from Oltrabella et al., 2021
pronephric duct cilium decreased length, abnormal	AB + MO1-ocrl	standard conditions	Fig. 5 from Oltrabella et al., 2015

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Citations

Include unpublished citations

Naylor, R.W., Lemarie, E., Jackson-Crawford, A., Davenport, J.B., Mironov, A., Lowe, M., Lennon, R. (2022) A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. Kidney International. 102(4):815-827
Oltrabella, F., Jackson-Crawford, A., Yan, G., Rixham, S., Starborg, T., Lowe, M. (2021) IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule. Human molecular genetics. 31(8):1183-1196
Ates, K.M., Wang, T., Moreland, T., Veeranan-Karmegam, R., Ma, M., Jeter, C., Anand, P., Wenzel, W., Kim, H.G., Wolfe, L.A., Stephen, J.A., Adams, D.R., Markello, T., Tifft, C.J., Settlage, R., Gahl, W.A., Gonsalvez, G.B., Malicdan, M.C., Flanagan-Steet, H., Pan, Y.A. (2020) Deficiency in the endocytic adaptor proteins PHETA1/2 impair renal and craniofacial development. Disease models & mechanisms. 13(5):
Oltrabella, F., Pietka, G., Ramirez, I.B., Mironov, A., Starborg, T., Drummond, I.A., Hinchliffe, K.A., Lowe, M. (2015) The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule. PLoS Genetics. 11:e1005058
Ramirez, I.B., Pietka, G., Jones, D.R., Divecha, N., Aliam, A., Baraban, S.C., Hurlstone, A.F., and Lowe, M. (2012) Impaired Neural Development in a Zebrafish Model for Lowe Syndrome. Human molecular genetics. 21(8):1744-1759

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