ZFIN Morpholino: MO1-nfe2l2b

Target Location

Genome Build: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-nfe2l2b

No data available

Phenotype

Phenotype resulting from MO1-nfe2l2b

Phenotype	Fish	Figures
anatomical structure glutathione disulfide decreased amount, abnormal	TL + MO1-nfe2l2b	Fig. 5 from Sant et al., 2017
anatomical structure glutathione disulfide increased amount, abnormal	TL + MO1-nfe2l2b	Fig. 5, Fig. 6 from Sant et al., 2017
glutathione disulfide oxidoreductase activity decreased occurrence, abnormal	TL + MO1-nfe2l2b	Fig. 5 from Sant et al., 2017
glutathione disulfide oxidoreductase activity increased occurrence, abnormal	TL + MO1-nfe2l2b	Fig. 6 from Sant et al., 2017
whole organism hsp70l expression increased amount, abnormal	TL + MO1-nfe2l2b	Fig. 8 from Sant et al., 2017

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Phenotype of all Fish created by or utilizing MO1-nfe2l2b

Phenotype	Fish	Conditions	Figures
glutathione disulfide oxidoreductase activity increased occurrence, abnormal	TL + MO1-nfe2l2b	chemical treatment by environment: tert-butyl hydroperoxide	Fig. 6 from Sant et al., 2017
anatomical structure glutathione disulfide increased amount, abnormal	TL + MO1-nfe2l2b	chemical treatment by environment: tert-butyl hydroperoxide	Fig. 6 from Sant et al., 2017
glutathione disulfide oxidoreductase activity increased occurrence, abnormal	TL + MO1-nfe2l2b	control	Fig. 6 from Sant et al., 2017
anatomical structure glutathione disulfide increased amount, abnormal	TL + MO1-nfe2l2b	control	Fig. 5, Fig. 6 from Sant et al., 2017
glutathione disulfide oxidoreductase activity decreased occurrence, abnormal	TL + MO1-nfe2l2b	standard conditions	Fig. 5 from Sant et al., 2017

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Citations

Include unpublished citations

Abate, G., Pezzotta, A., Pucci, M., Bortolotto, V., Ribaudo, G., Bonini, S.A., Mastinu, A., Maccarinelli, G., Ongaro, A., Tirelli, E., Zizioli, D., Gianoncelli, A., Memo, M., Grilli, M., Uberti, D. (2024) The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models. Antioxidants (Basel, Switzerland). 13(8):
Jin, B., Xie, L., Zhan, D., Zhou, L., Feng, Z., He, J., Qin, J., Zhao, C., Luo, L., Li, L. (2022) Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase. Development (Cambridge, England). 149(17)
Van Hall-Beauvais, A., Poganik, J.R., Huang, K.T., Parvez, S., Zhao, Y., Lin, H.Y., Liu, X., Long, M.J.C., Aye, Y. (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLIFE. 11:
Guan, R., Wen, X.Y., Leung, C.H., Ciano-Oliveira, C.D., Lam, S., Dai, S.Y., Karbassi, F., Mauro, A., Wang, Y., Rotstein, O. (2021) Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox. PLoS One. 16:e0260442
Sant, K.E., Moreau, H.M., Williams, L.M., Jacobs, H.M., Bowsher, A.M., Boisvert, J.D., Smolowitz, R.M., Pantazis, J., Annunziato, K., Nguyen, M., Timme-Laragy, A. (2020) Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease. 12(1):132-140
Sant, K.E., Hansen, J.M., Williams, L.M., Tran, N.L., Goldstone, J.V., Stegeman, J.J., Hahn, M.E., Timme-Laragy, A. (2017) The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology. 13:207-218
Williams, L.M., Timme-Laragy, A.R., Goldstone, J.V., McArthur, A.G., Stegeman, J.J., Smolowitz, R.M., and Hahn, M.E. (2013) Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One. 8(10):e79574
Timme-Laragy, A.R., Karchner, S.I., Franks, D.G., Jenny, M.J., Harbeitner, R.C., Goldstone, J.V., McArthur, A.G., and Hahn, M.E. (2012) Nrf2b: novel zebrafish paralog of the oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). The Journal of biological chemistry. 287(7):4609-4627

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