Gene

nfe2l2b

ID
ZDB-GENE-120320-3
Name
nfe2 like bZIP transcription factor 2b
Symbol
nfe2l2b Nomenclature History
Previous Names
  • Nrf2b (1)
  • si:dkey-3d18.4
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Sant et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfe2l2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency, developmental delay, and hypohomocysteinemia 617744
Associated With nfe2l2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004826 Basic leucine zipper domain, Maf-type
Domain IPR004827 Basic-leucine zipper domain
Family IPR029847 Endoplasmic reticulum membrane sensor NFE2L1
Homologous_superfamily IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Basic-leucine zipper domain Basic leucine zipper domain, Maf-type Endoplasmic reticulum membrane sensor NFE2L1 Transcription factor, Skn-1-like, DNA-binding domain superfamily
UniProtKB:G8DKA8 507
UniProtKB:E7FB56 507
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations