ZFIN ID: ZDB-GENE-120320-3
Gene Name: nuclear factor, erythroid 2-like 2b
Gene Symbol: nfe2l2b    Nomenclature History

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Previous Name: Nrf2b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress. Localizes to cytoplasm and nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).
Genome Resources: Alliance (1),  Gene:100873093 (1),  Ensembl(GRCz11):ENSDARG00000089697 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nfe2l2b N/A 3
DISEASE ASSOCIATED WITH nfe2l2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency, developmental delay, and hypohomocysteinemia 617744
DISEASE ASSOCIATED WITH nfe2l2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress (more)
Cellular Component cytoplasm (more)
Molecular Function DNA binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM nfe2l2b No data available
MARKER RELATIONSHIPS
nfe2l2b Contained in: [BAC] DKEY-3D18 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001257183 (1)
Genomic GenBank:BX546447 (1) 111358 nt
Select Tool
Polypeptide UniProtKB:E7FB56 (1) 507 aa
Sequence Information (all 8)
ORTHOLOGY for nfe2l2b ( Chr: 6 )
CITATIONS (25)