Gene
nfe2l2b
- ID
- ZDB-GENE-120320-3
- Name
- nfe2 like bZIP transcription factor 2b
- Symbol
- nfe2l2b Nomenclature History
- Previous Names
-
- Nrf2b (1)
- si:dkey-3d18.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Sant et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency, developmental delay, and hypohomocysteinemia | 617744 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Nuclear Factor Erythroid-derived 2-like | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:G8DKA8 | InterPro | 507 | ||||
| UniProtKB:A0AB32TUN3 | InterPro | 475 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfe2l2b-201
(1)
|
Ensembl | 3,002 nt |
Interactions and Pathways
No data available
Plasmids