Gene
nfe2l2b
- ID
- ZDB-GENE-120320-3
- Name
- nfe2 like bZIP transcription factor 2b
- Symbol
- nfe2l2b Nomenclature History
- Previous Names
-
- Nrf2b (1)
- si:dkey-3d18.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; and macular degeneration. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human NFE2L2 (nuclear factor, erythroid 2 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Sant et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency, developmental delay, and hypohomocysteinemia | 617744 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Nuclear Factor Erythroid-derived 2-like | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:G8DKA8
|
507 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
nfe2l2b-201
(1)
|
Havana | 3002 nt |
Interactions and Pathways
No data available
Plasmids