ZFIN Morpholino: MO1-lta4h

Target Location

Genome Build: GRCz11Chromosome: 4

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-lta4h

No data available

Phenotype

Phenotype resulting from MO1-lta4h

Phenotype	Fish	Figures
epiboly involved in gastrulation with mouth forming second delayed, abnormal	AB + MO1-lta4h	Fig. 10 from Okuno et al., 2015
neutrophil chemotaxis decreased occurrence, abnormal	i114Tg + MO1-lta4h	Fig. S3 from de Oliveira et al., 2015

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Phenotype of all Fish created by or utilizing MO1-lta4h

Phenotype	Fish	Conditions	Figures
epiboly involved in gastrulation with mouth forming second delayed, abnormal	AB + MO1-lta4h	standard conditions	Fig. 10 from Okuno et al., 2015
defense response to bacterium disrupted, abnormal	AB + MO1-lta4h	bacterial treatment: Mycobacterium marinum	Fig. 2 from Tobin et al., 2012
inflammatory response to antigenic stimulus process quality, abnormal	AB + MO1-lta4h	bacterial treatment: Mycobacterium marinum	Fig. 2 from Tobin et al., 2012
whole organism decreased life span, exacerbated	WT + MO1-lta4h	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 8 from Tyrkalska et al., 2016
neutrophil chemotaxis decreased occurrence, abnormal	i114Tg + MO1-lta4h	control	Fig. S3 from de Oliveira et al., 2015

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Citations

Include unpublished citations

Tyrkalska, S.D., Candel, S., Angosto, D., Gómez-Abellán, V., Martín-Sánchez, F., García-Moreno, D., Zapata-Pérez, R., Sánchez-Ferrer, Á., Sepulcre, M.P., Pelegrín, P., Mulero, V. (2016) Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nature communications. 7:12077
de Oliveira, S., Boudinot, P., Calado, Â., Mulero, V. (2015) Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. Journal of immunology (Baltimore, Md. : 1950). 194(4):1523-33
Oehlers, S.H., Cronan, M.R., Scott, N.R., Thomas, M.I., Okuda, K.S., Walton, E.M., Beerman, R.W., Crosier, P.S., Tobin, D.M. (2015) Interception of host angiogenic signalling limits mycobacterial growth. Nature. 517(7536):612-5
Okuno, T., Ishitani, T., Yokomizo, T. (2015) Biochemical Characterization of Three BLT Receptors in Zebrafish. PLoS One. 10:e0117888
Enyedi, B., Kala, S., Nikolich-Zugich, T., and Niethammer, P. (2013) Tissue damage detection by osmotic surveillance. Nature cell biology. 15(9):1123-30
Roca, F.J., and Ramakrishnan, L. (2013) TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species. Cell. 153(3):521-34
Tobin, D.M., Roca, F.J., Oh, S.F., McFarland, R., Vickery, T.W., Ray, J.P., Ko, D.C., Zou, Y., Bang, N.D., Chau, T.T., Vary, J.C., Hawn, T.R., Dunstan, S.J., Farrar, J.J., Thwaites, G.E., King, M.C., Serhan, C.N., and Ramakrishnan, L. (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 148(3):434-446
Tobin, D.M., Vary, J.C. Jr, Ray, J.P., Walsh, G.S., Dunstan, S.J., Bang, N.D., Hagge, D.A., Khadge, S., King, M.C., Hawn, T.R., Moens, C.B., and Ramakrishnan, L. (2010) The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans. Cell. 140(5):717-730

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