ZFIN Morpholino: MO2-itga7

Target Location

Genome Build: GRCz11Chromosome: 11

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-itga7

Expressed Gene	Anatomy	Figures
itga7	whole organism	Fig. S4 from Postel et al., 2008
pxna	myotome muscle tendon junction vertical myoseptum	Fig. 7 from Goody et al., 2012

Phenotype

Phenotype resulting from MO2-itga7

Phenotype	Fish	Figures
locomotion involved in locomotory behavior decreased rate, abnormal	WT + MO2-itga7	Fig. 8 from Goody et al., 2012
myotome muscle cell detached from myotome muscle tendon junction, abnormal	WT + MO2-itga7	Fig. 3 , Fig. 7 from Goody et al., 2012
skeletal muscle cell actin cytoskeleton retracted, abnormal	WT + MO2-itga7	Fig. 3 from Postel et al., 2008
whole organism paralysed, abnormal	WT + MO2-itga7	Fig. 3 from Postel et al., 2008

Phenotype of all Fish created by or utilizing MO2-itga7

Phenotype	Fish	Conditions	Figures
whole organism paralysed, abnormal	WT + MO2-itga7	standard conditions	Fig. 3 from Postel et al., 2008
locomotion involved in locomotory behavior decreased rate, abnormal	WT + MO2-itga7	standard conditions	Fig. 8 from Goody et al., 2012
skeletal muscle cell actin cytoskeleton retracted, abnormal	WT + MO2-itga7	standard conditions	Fig. 3 from Postel et al., 2008
myotome muscle cell detached from myotome muscle tendon junction, abnormal	WT + MO2-itga7	standard conditions	Fig. 3 , Fig. 7 from Goody et al., 2012
locomotion involved in locomotory behavior decreased rate, abnormal	WT + MO2-itga7	chemical treatment: NAD(+)	Fig. 8 from Goody et al., 2012
myotome muscle cell degenerate, abnormal	WT + MO1-dag1 + MO2-itga7	chemical treatment: NAD(+)	Fig. 3 from Goody et al., 2012
myotome muscle cell degenerate, abnormal	WT + MO1-dag1 + MO2-itga7	standard conditions	Fig. 3 from Goody et al., 2012
myotome muscle tendon junction malformed, abnormal	WT + MO1-dag1 + MO2-itga7	chemical treatment: NAD(+)	Fig. 3 from Goody et al., 2012
vertical myoseptum malformed, abnormal	WT + MO1-dag1 + MO2-itga7	standard conditions	Fig. 3 from Goody et al., 2012
myotome muscle cell detached from myotome muscle tendon junction, abnormal	WT + MO1-dag1 + MO2-itga7	standard conditions	Fig. 3 from Goody et al., 2012
vertical myoseptum malformed, abnormal	WT + MO1-dag1 + MO2-itga7	chemical treatment: NAD(+)	Fig. 3 from Goody et al., 2012
myotome muscle tendon junction malformed, abnormal	WT + MO1-dag1 + MO2-itga7	standard conditions	Fig. 3 from Goody et al., 2012
myotome muscle cell detached from myotome muscle tendon junction, abnormal	WT + MO1-dag1 + MO2-itga7	chemical treatment: NAD(+)	Fig. 3 from Goody et al., 2012
myotome muscle cell detached from myotome muscle tendon junction, abnormal	mai1Tg + MO2-itga7	standard conditions	Fig. 7 from Goody et al., 2012
locomotion involved in locomotory behavior decreased rate, abnormal	mai1Tg + MO2-itga7	standard conditions	Fig. 8 from Goody et al., 2012
skeletal muscle cell sarcolemma retracted, abnormal	vu119Tg + MO2-itga7	standard conditions	Fig. S5 from Postel et al., 2008
skeletal muscle cell actin cytoskeleton retracted, abnormal	vu119Tg + MO2-itga7	standard conditions	Fig. S5 from Postel et al., 2008

Citations

Include unpublished citations

Goody, M.F., Kelly, M.W., Reynolds, C.J., Khalil, A., Crawford, B.D., and Henry, C.A. (2012) NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. PLoS Biology. 10(10):e1001409
Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology. 318(1):92-101

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