ZFIN Morpholino: MO3-sox32

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-sox32

Expressed Gene	Anatomy	Figures
cxcl12b	head endoderm	Fig. 4 from Siekmann et al., 2009
kdrl	lateral dorsal aorta	Fig. 4 from Siekmann et al., 2009

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Phenotype

Phenotype resulting from MO3-sox32

Phenotype	Fish	Figures
blood circulation arrested, abnormal	WT + MO3-sox32	Fig. 4 from Siekmann et al., 2009
endoderm aplastic, abnormal	la116Tg + MO3-sox32	Fig. 4 , Fig. S7 from Siekmann et al., 2009
lateral dorsal aorta malformed, abnormal	la116Tg + MO3-sox32	Fig. 4 , Fig. S7 from Siekmann et al., 2009
lymphangioblast cord decreased length, abnormal	nz101Tg + MO3-sox32	Fig. 4 from Nicenboim et al., 2015
vasculogenesis process quality, abnormal	la116Tg + MO3-sox32	Fig. 4 , Fig. S7 from Siekmann et al., 2009

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Phenotype of all Fish created by or utilizing MO3-sox32

Phenotype	Fish	Conditions	Figures
blood circulation arrested, abnormal	WT + MO3-sox32	standard conditions	Fig. 4 from Siekmann et al., 2009
lateral dorsal aorta malformed, abnormal	WT + MO3-sox32	standard conditions	Fig. 4 from Siekmann et al., 2009
vasculogenesis process quality, abnormal	WT + MO3-sox32	standard conditions	Fig. 4 from Siekmann et al., 2009
endoderm aplastic, abnormal	WT + MO3-sox32	standard conditions	Fig. 4 from Siekmann et al., 2009
endoderm aplastic, abnormal	la116Tg + MO3-sox32	standard conditions	Fig. S7 from Siekmann et al., 2009

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Citations

Include unpublished citations

Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Helker, C.S., Schuermann, A., Karpanen, T., Zeuschner, D., Belting, H.G., Affolter, M., Schulte-Merker, S., and Herzog, W. (2013) The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment. Development (Cambridge, England). 140(13):2776-2786
Stückemann, T., Wegleiter, T., Stefan, E., Nägele, O., Tarbashevich, K., Böck, G., Raz, E., and Aanstad, P. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development (Cambridge, England). 139(15):2711-2720
Chan, T.M., Chao, C.H., Wang, H.D., Yu, Y.J., and Yuh, C.H. (2009) Functional analysis of the evolutionarily conserved Cis-regulatory elements on the Sox17 gene in zebrafish. Developmental Biology. 326(2):456-470
Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., and Lawson, N.D. (2009) Chemokine signaling guides regional patterning of the first embryonic artery. Genes & Development. 23(19):2272-2277
Chung, W.S., and Stainier, D.Y. (2008) Intra-endodermal interactions are required for pancreatic beta cell induction. Developmental Cell. 14(4):582-593
Griffin, K.J.P. and Kimelman, D. (2002) One-Eyed Pinhead and Spadetail are essential for heart and somite formation. Nature cell biology. 4(10):821-825

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