ZFIN Morpholino: MO1-cdkn1a

Target Location

Genome Build: GRCz11Chromosome: 22

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cdkn1a

No data available

Phenotype

Phenotype resulting from MO1-cdkn1a

Phenotype	Fish	Figures
apoptotic process decreased occurrence, abnormal	AB + MO1-cdkn1a	Fig. 3 from Liu et al., 2009
gastrulation with mouth forming second disrupted, abnormal	AB + MO1-cdkn1a	Fig. 1 from Liu et al., 2009
regulation of mitotic cell cycle, embryonic disrupted, abnormal	AB + MO1-cdkn1a	Fig. 1 from Liu et al., 2009
whole organism cdkn1a expression decreased amount, abnormal	WT + MO1-cdkn1a	Fig. 6 from Honjo et al., 2019

1 - 4 of 4

Phenotype of all Fish created by or utilizing MO1-cdkn1a

Phenotype	Fish	Conditions	Figures
regulation of mitotic cell cycle, embryonic disrupted, abnormal	AB + MO1-cdkn1a	standard conditions	Fig. 1 from Liu et al., 2009
apoptotic process decreased occurrence, abnormal	AB + MO1-cdkn1a	standard conditions	Fig. 3 from Liu et al., 2009
gastrulation with mouth forming second disrupted, abnormal	AB + MO1-cdkn1a	standard conditions	Fig. 1 from Liu et al., 2009
whole organism cdkn1a expression decreased amount, abnormal	WT + MO1-cdkn1a	standard conditions	Fig. 6 from Honjo et al., 2019
epidermis somatic stem cell amount, ameliorated	klf4^as32/+ + MO1-cdkn1a	standard conditions	Fig. S6 from Chen et al., 2019

1 - 5 of 7 Show all

Citations

Include unpublished citations

Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
Chen, Y.C., Liao, B.K., Lu, Y.F., Liu, Y.H., Hsieh, F.C., Hwang, P.P., Hwang, S.L. (2019) Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition. PLoS Genetics. 15:e1008058
Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
Davidson, W.R., Kari, C., Ren, Q., Daroczi, B., Dicker, A.P., and Rodeck, U. (2010) Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos. BMC Developmental Biology. 10:102
Liu, X., Huang, S., Ma, J., Li, C., Zhang, Y., and Luo, L. (2009) NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. The Journal of cell biology. 184(6):805-815
Sidi, S., Sanda, T., Kennedy, R.D., Hagen, A.T., Jette, C.A., Hoffmans, R., Pascual, J., Imamura, S., Kishi, S., Amatruda, J.F., Kanki, J.P., Green, D.R., D'Andrea, A.A., and Look, A.T. (2008) Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3. Cell. 133(5):864-877

1 - 7 of 7

Show