ZFIN Morpholino: MO4-smo

Target Location

Genome Build: GRCz11Chromosome: 4

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-smo

Phenotype

Phenotype resulting from MO4-smo

Phenotype	Fish	Figures
endocardium development disrupted, abnormal	WT + MO4-smo	Fig. 7 from Wong et al., 2012
head decreased size, abnormal	WT + MO4-smo	Fig. 1 from Robu et al., 2007
nervous system apoptotic, abnormal	WT + MO4-smo	Fig. 1 , Fig. 2 from Robu et al., 2007
somite shape, abnormal	WT + MO4-smo + MO4-tp53	Fig. 1 from Robu et al., 2007
spinal cord curved, abnormal	WT + MO4-smo	Fig. 1 from Robu et al., 2007

Phenotype of all Fish created by or utilizing MO4-smo

Phenotype	Fish	Conditions	Figures
nervous system apoptotic, abnormal	WT + MO4-smo	standard conditions	Fig. 1 , Fig. 2 from Robu et al., 2007
head decreased size, abnormal	WT + MO4-smo	standard conditions	Fig. 1 from Robu et al., 2007
endocardium development disrupted, abnormal	WT + MO4-smo	standard conditions	Fig. 7 from Wong et al., 2012
somite shape, abnormal	WT + MO4-smo	standard conditions	Fig. 1 from Robu et al., 2007
spinal cord curved, abnormal	WT + MO4-smo	standard conditions	Fig. 1 from Robu et al., 2007
somite shape, abnormal	WT + MO4-smo + MO4-tp53	standard conditions	Fig. 1 from Robu et al., 2007
spinal cord curved, abnormal	WT + MO4-smo + MO4-tp53	standard conditions	Fig. 1 from Robu et al., 2007

Citations

Include unpublished citations

Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L., and Zhao, Y. (2013) Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology. 203(4):575-583
Stückemann, T., Wegleiter, T., Stefan, E., Nägele, O., Tarbashevich, K., Böck, G., Raz, E., and Aanstad, P. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development (Cambridge, England). 139(15):2711-2720
Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S. (2012) Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish. Developmental Biology. 361(2):377-91
Glazer, A., Wilkinson, A., Backer, C.B., Lapan, S., Gutzman, J.H., Cheeseman, I.M., and Reddien, P.W. (2010) The Zn Finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Developmental Biology. 337(1):148-156
Mich, J.K., Blaser, H., Thomas, N.A., Firestone, A.J., Yelon, D., Raz, E., and Chen, J.K. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328(2):342-354
Robu, M.E., Larson, J.D., Nasevicius, A., Beiraghi, S., Brenner, C., Farber, S.A., and Ekker, S.C. (2007) p53 activation by knockdown technologies. PLoS Genetics. 3(5):e78

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