Gene

smo

ID

ZDB-GENE-980526-89

Name

smoothened, frizzled class receptor

Symbol

smo Nomenclature History

Previous Names

CHUNP6862
slow muscle omitted
smoh
smoothened (1)
smu
wu:fb70b01
wu:fc39h03

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Exhibits oxysterol binding activity. Involved in several processes, including animal organ development; blood vessel development; and nervous system development. Localizes to cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 104 figures from 65 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smo Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Basal cell carcinoma, somatic	605462
		Curry-Jones syndrome, somatic mosaic	601707
		Pallister-Hall-like syndrome	241800

Associated With smo Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000539	Frizzled/Smoothened, transmembrane domain
Domain	IPR017981	GPCR, family 2-like
Domain	IPR020067	Frizzled domain
Domain	IPR035683	Smoothened, transmembrane domain
Domain	IPR041771	Smoothened, cysteine-rich domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Family	IPR026544	Smoothened
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily