Gene

smo

ID

ZDB-GENE-980526-89

Name

smoothened, frizzled class receptor

Symbol

smo Nomenclature History

Previous Names

CHUNP6862
slow muscle omitted
smoh
smoothened (1)
smu
wu:fb70b01
wu:fc39h03

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Enables oxysterol binding activity. Involved in exocrine pancreas development. Acts upstream of or within several processes, including circulatory system development; embryonic organ development; and nervous system development. Located in cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 106 figures from 66 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smo Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Basal cell carcinoma, somatic	605462
		Curry-Jones syndrome, somatic mosaic	601707
		Pallister-Hall-like syndrome	241800

Associated With smo Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000539	Frizzled/Smoothened, 7TM
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR020067	Frizzled domain
Domain	IPR035683	Smoothened, 7TM
Domain	IPR041771	Smoothened, cysteine-rich domain
Family	IPR015526	Frizzled/secreted frizzled-related protein
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Frizzled cysteine-rich domain superfamily	Frizzled domain	Frizzled/secreted frizzled-related protein	Frizzled/Smoothened, 7TM	GPCR, family 2-like, 7TM	Smoothened, 7TM	Smoothened, cysteine-rich domain
UniProtKB:Q5RH73	InterPro PDB	822

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	smo-201 (1) Ensembl	Ensembl		6,212 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations