ZFIN Morpholino: MO6-notch3

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO6-notch3

No data available

Phenotype

Phenotype resulting from MO6-notch3

Phenotype	Fish	Figures
dorsal telencephalon radial glial cell proliferative, abnormal	AB + MO6-notch3	Fig. 5 from Alunni et al., 2013
hematopoietic progenitor cell differentiation process quality, abnormal	AB + MO6-notch3	Fig. 1, Fig. 6 from Kim et al., 2014
hematopoietic stem cell differentiation process quality, abnormal	AB + MO6-notch3	Fig. 1 from Kim et al., 2014
hemopoiesis process quality, abnormal	AB + MO6-notch3	Fig. 1 from Kim et al., 2014
radial glial cell division in pallium increased occurrence, abnormal	AB + MO6-notch3	Fig. 5 from Alunni et al., 2013

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Phenotype of all Fish created by or utilizing MO6-notch3

Phenotype	Fish	Conditions	Figures
dorsal telencephalon radial glial cell proliferative, abnormal	AB + MO6-notch3	standard conditions	Fig. 5 from Alunni et al., 2013
hematopoietic stem cell differentiation process quality, abnormal	AB + MO6-notch3	standard conditions	Fig. 1 from Kim et al., 2014
radial glial cell division in pallium increased occurrence, abnormal	AB + MO6-notch3	standard conditions	Fig. 5 from Alunni et al., 2013
hematopoietic progenitor cell differentiation process quality, abnormal	AB + MO6-notch3	standard conditions	Fig. 1, Fig. 6 from Kim et al., 2014
hemopoiesis process quality, abnormal	AB + MO6-notch3	standard conditions	Fig. 1 from Kim et al., 2014

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Citations

Include unpublished citations

Lu, Y.F., Liu, D.W., Li, I.C., Lin, J., Wang, C.M., Chu, K.C., Kuo, H.H., Lin, C.Y., Yih, L.H., Jiang, Y.J., Hwang, S.L. (2021) Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. PLoS Genetics. 17:e1009969
Campbell, L.J., Hobgood, J.S., Jia, M., Boyd, P., Hipp, R.I., Hyde, D.R. (2020) Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light-damaged zebrafish retina. Glia. 69(3):546-566
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73
Alunni, A., Krecsmarik, M., Bosco, A., Galant, S., Pan, L., Moens, C.B., and Bally-Cuif, L. (2013) Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium. Development (Cambridge, England). 140(16):3335-47
Ma, M., and Jiang, Y.J. (2007) Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genetics. 3(1):e18

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