ZFIN Morpholino: MO1-smad1

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-smad1

Expressed Gene	Anatomy	Figures
gata1a	blood intermediate cell mass of mesoderm lateral mesoderm	Fig. 4, Fig. 6 from McReynolds et al., 2007
gata2a	lateral mesoderm presumptive ectoderm (not) whole organism	Fig. 3 from Dee et al., 2007 Fig. 4 from McReynolds et al., 2007
hbbe3	nucleate erythrocyte	Fig. 3 from McReynolds et al., 2007
lcp1	(not) blood	Fig. 6 from McReynolds et al., 2007
lmo2	intermediate cell mass of mesoderm lateral mesoderm	Fig. 4, Fig. 6 from McReynolds et al., 2007

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Phenotype

Phenotype resulting from MO1-smad1

Phenotype	Fish	Figures
brain morphology, abnormal	WT + MO1-smad1	Fig. 2 from McReynolds et al., 2007
cloacal chamber cellular quality, abnormal	WT + MO1-smad1	Fig. s4 from Laux et al., 2011
ectodermal cell fate commitment disrupted, abnormal	WT + MO1-smad1	Fig. 3 from Dee et al., 2007
endoderm morphology, abnormal	WT + MO1-smad1	Fig. 2 from McReynolds et al., 2007
endoderm formation disrupted, abnormal	WT + MO1-smad1	Fig. 2 from McReynolds et al., 2007

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Phenotype of all Fish created by or utilizing MO1-smad1

Phenotype	Fish	Conditions	Figures
endoderm formation disrupted, abnormal	WT + MO1-smad1	standard conditions	Fig. 2 from McReynolds et al., 2007
neuroectoderm degenerate, abnormal	WT + MO1-smad1	standard conditions	Fig. 2 from McReynolds et al., 2007
extension morphology, abnormal	WT + MO1-smad1	standard conditions	Fig. 2 from McReynolds et al., 2007
epiphysis cellular quality, abnormal	WT + MO1-smad1	standard conditions	Fig. T1 from Laux et al., 2011
heart cellular quality, abnormal	WT + MO1-smad1	standard conditions	Fig. T1 from Laux et al., 2011

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Citations

Include unpublished citations

Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453
Watterston, C., Zeng, L., Onabadejo, A., Childs, S.J. (2019) MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling. PLoS Genetics. 15:e1008163
Wang, Y., Li, W.H., Li, Z., Liu, W., Zhou, L., Gui, J.F. (2015) BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Gene. 554:196-204
Xue, Y., Zheng, X., Huang, L., Xu, P., Ma, Y., Min, Z., Tao, Q., Tao, Y., Meng, A. (2014) Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature communications. 5:3766
Laux, D.W., Febbo, J.A., and Roman, B.L. (2011) Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(3):682-694
Dee, C.T., Gibson, A., Rengifo, A., Sun, S.K., Patient, R.K., and Scotting, P.J. (2007) A change in response to Bmp signalling precedes ectodermal fate choice. The International journal of developmental biology. 51(1):79-84
McReynolds, L.J., Gupta, S., Figueroa, M.E., Mullins, M.C., and Evans, T. (2007) Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 110(12):3881-3890

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