ZFIN Morpholino: MO1-en2a

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-en2a

Expressed Gene	Anatomy	Figures
en2b	midbrain hindbrain boundary midbrain hindbrain boundary neural keel optic stalk otic vesicle (all 4)	Fig. 1 from Scholpp et al., 2001

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Phenotype

Phenotype resulting from MO1-en2a

Phenotype	Fish	Figures
optic tectum decreased size, abnormal	WT + MO1-en2a	Fig. 1 from Scholpp et al., 2001

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Phenotype of all Fish created by or utilizing MO1-en2a

Phenotype	Fish	Conditions	Figures
optic tectum decreased size, abnormal	WT + MO1-en2a	standard conditions	Fig. 1 from Scholpp et al., 2001
brain lacks all parts of type midbrain hindbrain boundary, abnormal	WT + MO1-en2a + MO1-en2b	standard conditions	Fig. 1, Fig. 2 from Scholpp et al., 2001
brain lacks all parts of type optic tectum, abnormal	WT + MO1-en2a + MO1-en2b	standard conditions	Fig. 1, Fig. 2 from Scholpp et al., 2001
midbrain-hindbrain boundary development disrupted, abnormal	WT + MO1-en2a + MO1-en2b	standard conditions	Fig. 1, Fig. 2 from Scholpp et al., 2001
midbrain development disrupted, abnormal	WT + MO1-en2a + MO1-en2b	standard conditions	Fig. 2 from Scholpp et al., 2001

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Citations

Include unpublished citations

Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
Dworkin, S., Darido, C., Georgy, S.R., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J.K., Lieschke, G.J., and Jane, S.M. (2012) Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development (Cambridge, England). 139(3):525-536
Erickson, T., Scholpp, S., Brand, M., Moens, C.B., and Waskiewicz, A. Jan (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology. 301(2):504-517
Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239
Scholpp, S. and Brand, M. (2001) Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain–hindbrain boundary development. Genesis (New York, N.Y. : 2000). 30(3):129-133

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