ZFIN Morpholino: MO2-tfap2a

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-tfap2a

Expressed Gene	Anatomy	Figures
hand2	endoderm heart tube (not) pharyngeal arch 4 skeleton	Fig. 5 from Wendl et al., 2007

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Phenotype

Phenotype resulting from MO2-tfap2a

Phenotype	Fish	Figures
ceratohyal cartilage hypoplastic, abnormal	WT + MO2-tfap2a	Fig. 4 from Gestri et al., 2009
ceratohyal cartilage medially rotated, abnormal	WT + MO2-tfap2a	Fig. 4 from Gestri et al., 2009
eye decreased size, abnormal	WT + MO2-tfap2a	Fig. 4 from Gestri et al., 2009
melanocyte decreased amount, abnormal	WT + MO2-tfap2a	Fig. 6 from Van Otterloo et al., 2010
optic fissure closure incomplete, abnormal	WT + MO2-tfap2a	Fig. 4 from Gestri et al., 2009

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Phenotype of all Fish created by or utilizing MO2-tfap2a

Phenotype	Fish	Conditions	Figures
ceratohyal cartilage hypoplastic, abnormal	WT + MO2-tfap2a	standard conditions	Fig. 4 from Gestri et al., 2009
ceratohyal cartilage medially rotated, abnormal	WT + MO2-tfap2a	standard conditions	Fig. 4 from Gestri et al., 2009
retinal pigmented epithelium protruding, abnormal	WT + MO2-tfap2a	standard conditions	Fig. 4 from Gestri et al., 2009
retinal pigmented epithelium mislocalised, abnormal	WT + MO2-tfap2a	standard conditions	Fig. 4 from Gestri et al., 2009
melanocyte decreased amount, abnormal	WT + MO2-tfap2a	standard conditions	Fig. 6 from Van Otterloo et al., 2010

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Citations

Include unpublished citations

Van Otterloo, E., Li, W., Bonde, G., Day, K.M., Hsu, M.Y., and Cornell, R.A. (2010) Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genetics. 6(9):pii: e1001122
Gestri, G., Osborne, R.J., Wyatt, A.W., Gerrelli, D., Gribble, S., Stewart, H., Fryer, A., Bunyan, D.J., Prescott, K., Collin, J.R., Fitzgerald, T., Robinson, D., Carter, N.P., Wilson, S.W., and Ragge, N.K. (2009) Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators. Human genetics. 126(6):791-803
Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879
O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004) Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology. 265(1):246-261
Knight, R.D., Nair, S., Nelson, S.S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.J., and Schilling, T.F. (2003) lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development (Cambridge, England). 130(23):5755-5768

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