ZFIN Morpholino: MO2-tbxta

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-tbxta

No data available

Phenotype

Phenotype resulting from MO2-tbxta

Phenotype	Fish	Figures
determination of liver left/right asymmetry decreased occurrence, abnormal	AB + MO2-tbxta	Fig. 5 from Nelson et al., 2017
determination of pancreatic left/right asymmetry decreased occurrence, abnormal	AB + MO2-tbxta	Fig. 5 from Nelson et al., 2017
digestive system foxa3 expression spatial pattern, abnormal	AB + MO2-tbxta	Fig. 5 from Nelson et al., 2017
digestive tract development process quality, abnormal	AB + MO2-tbxta	Fig. 5 from Nelson et al., 2017
liver position, abnormal	AB + MO2-tbxta	Fig. 5 from Nelson et al., 2017

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Phenotype of all Fish created by or utilizing MO2-tbxta

Phenotype	Fish	Conditions	Figures
pancreas development process quality, abnormal	AB + MO2-tbxta	standard conditions	Fig. 5 from Nelson et al., 2017
digestive tract development process quality, abnormal	AB + MO2-tbxta	standard conditions	Fig. 5 from Nelson et al., 2017
liver development process quality, abnormal	AB + MO2-tbxta	standard conditions	Fig. 5 from Nelson et al., 2017
pancreas ins expression spatial pattern, abnormal	AB + MO2-tbxta	standard conditions	Fig. 5 from Nelson et al., 2017
pancreas position, abnormal	AB + MO2-tbxta	standard conditions	Fig. 5 from Nelson et al., 2017

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Citations

Include unpublished citations

Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
Nelson, A.C., Cutty, S.J., Gasiunas, S.N., Deplae, I., Stemple, D.L., Wardle, F.C. (2017) In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors. Cell Reports. 19:2782-2795
Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007
Jahangiri, L., Nelson, A.C., Wardle, F.C. (2012) A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites. Developmental Biology. 371:110-120
Harvey, S.A., Tümpel, S., Dubrulle, J., Schier, A.F., and Smith, J.C. (2010) no tail integrates two modes of mesoderm induction. Development (Cambridge, England). 137(7):1127-1135
Morley, R.H., Lachani, K., Keefe, D., Gilchrist, M.J., Flicek, P., Smith, J.C., and Wardle, F.C. (2009) A gene regulatory network directed by zebrafish No tail accounts for its roles in mesoderm formation. Proceedings of the National Academy of Sciences of the United States of America. 106(10):3829-3834
Regan, J.C., Concha, M.L., Roussigne, M., Russell, C., and Wilson, S.W. (2009) An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry. Neuron. 61(1):27-34
Feldman, B. and Stemple, D.L. (2001) Morpholino phenocopies of sqt, oep, and ntl mutations. Genesis (New York, N.Y. : 2000). 30(3):175-177

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