ZFIN Morpholino: MO1-smyd1b

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-smyd1b

Expressed Gene	Anatomy	Figures
hsp90aa1.1	skeletal muscle cell	Fig. 5 from Li et al., 2013
myf5	somite	Fig. S9 from Tan et al., 2006
myhz2	skeletal muscle	Fig. 8 from Li et al., 2013
myod1	somite	Fig. S9 from Tan et al., 2006
myog	somite	Fig. S9 from Tan et al., 2006
smyhc1	skeletal muscle slow muscle cell cytoplasm	Fig. 8 from Li et al., 2013 Fig. 3 from Xu et al., 2012
trim55a	myotome skeletal muscle cell	Fig. 5 from Li et al., 2019
trim63a	myotome skeletal muscle cell primitive heart tube cardiac muscle cell	Fig. 5 from Li et al., 2019
unc45b	skeletal muscle cell	Fig. 5 from Li et al., 2013

Phenotype

Phenotype resulting from MO1-smyd1b

Phenotype	Fish	Figures
cardiac muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	Fig. 4 from Li et al., 2013
cardiac muscle myosin thick filament assembly disrupted, abnormal	WT + MO1-smyd1b	Fig. 4 from Li et al., 2013
fast muscle cell M band disorganized, abnormal	WT + MO1-smyd1b	Fig. 2 from Li et al., 2013
fast muscle cell muscle thin filament assembly disrupted, abnormal	WT + MO1-smyd1b	Fig. 2 from Li et al., 2013
fast muscle cell sarcomere organization disrupted, abnormal	WT + MO1-smyd1b	Fig. 2 from Li et al., 2013
fast muscle cell striated muscle myosin thick filament assembly disrupted, abnormal	WT + MO1-smyd1b	Fig. 2 from Li et al., 2013
fast muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	Fig. 2 from Li et al., 2013
skeletal muscle striated muscle thin filament disorganized, abnormal	WT + MO1-smyd1b	Fig. 4 from Gao et al., 2014
slow muscle cell myofibril assembly disrupted, abnormal	WT + MO1-smyd1b	Fig. 1 from Li et al., 2013
slow muscle cell myosin filament disorganized, abnormal	WT + MO1-smyd1b	Fig. 3 from Gao et al., 2014
slow muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	Fig. 5 from Gao et al., 2014

Phenotype of all Fish created by or utilizing MO1-smyd1b

Phenotype	Fish	Conditions	Figures
fast muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 2 from Li et al., 2013
slow muscle cell myosin filament disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 3 from Gao et al., 2014
skeletal muscle striated muscle thin filament disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 4 from Gao et al., 2014
fast muscle cell M band disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 2 from Li et al., 2013
fast muscle cell muscle thin filament assembly disrupted, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 2 from Li et al., 2013
slow muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 5 from Gao et al., 2014
fast muscle cell striated muscle myosin thick filament assembly disrupted, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 2 from Li et al., 2013
slow muscle cell myofibril assembly disrupted, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 1 from Li et al., 2013
cardiac muscle myosin thick filament assembly disrupted, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 4 from Li et al., 2013
cardiac muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 4 from Li et al., 2013
fast muscle cell sarcomere organization disrupted, abnormal	WT + MO1-smyd1b	standard conditions	Fig. 2 from Li et al., 2013
skeletal muscle striated muscle thin filament disorganized, abnormal	WT + MO1-smyd1a + MO1-smyd1b	standard conditions	Fig. 4 from Gao et al., 2014
slow muscle cell Z disc disorganized, abnormal	WT + MO1-smyd1a + MO1-smyd1b	standard conditions	Fig. 5 from Gao et al., 2014
slow muscle cell myosin filament disorganized, abnormal	WT + MO1-smyd1a + MO1-smyd1b	standard conditions	Fig. 3 from Gao et al., 2014
skeletal muscle cell EGFP expression spatial pattern, abnormal	mb19Tg + MO1-smyd1b	standard conditions	Fig. 6 from Li et al., 2019
skeletal muscle cell M band EGFP expression absent, abnormal	mb19Tg + MO1-smyd1b	standard conditions	Fig. 6 from Li et al., 2019

Citations

Include unpublished citations

Li, B., Li, S., He, Q., Du, S. (2019) Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 240:110368
Gao, J., Li, J., Li, B.J., Yagil, E., Zhang, J., and Du, S.J. (2014) Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. PLoS One. 9(1):e86808
Li, H., Zhong, Y., Wang, Z., Gao, J., Xu, J., Chu, W., Zhang, J., Fang, S., and Du, S.J. (2013) Smyd1b is required for skeletal and cardiac muscle function in zebrafish. Molecular biology of the cell. 24(22):3511-21
Xu, J., Gao, J., Li, J., Xue, L., Clark, K.J., Ekker, S.C., and Du, S.J. (2012) Functional analysis of slow Myosin heavy chain 1 and myomesin-3 in sarcomere organization in zebrafish embryonic slow muscles. Journal of genetics and genomics = Yi chuan xue bao. 39(2):69-80
Tan, X., Rotllant, J., Li, H., Dedeyne, P., and Du, S.J. (2006) SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos. Proceedings of the National Academy of Sciences of the United States of America. 103(8):2713-2718

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