ZFIN Morpholino: MO4-cxcl12a

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-cxcl12a

No data available

Phenotype

Phenotype resulting from MO4-cxcl12a

Phenotype	Fish	Figures
axon guidance process quality, abnormal	WT + MO4-cxcl12a	Fig. S4 from Hollway et al., 2007
hypaxial myotome region aplastic, abnormal	zf13Tg + MO4-cxcl12a	Fig. 6 from Hollway et al., 2007
muscle cell migration arrested, abnormal	WT + MO4-cxcl12a	Fig. 6 from Hollway et al., 2007
muscle cell migration disrupted, abnormal	WT + MO4-cxcl12a	Fig. S5 from Hollway et al., 2007
myotome cellular quality, abnormal	WT + MO4-cxcl12a	Fig. S5 from Hollway et al., 2007

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Phenotype of all Fish created by or utilizing MO4-cxcl12a

Phenotype	Fish	Conditions	Figures
trigeminal ganglion axon position, abnormal	WT + MO4-cxcl12a	standard conditions	Fig. S4 from Hollway et al., 2007
myotome cellular quality, abnormal	WT + MO4-cxcl12a	standard conditions	Fig. S5 from Hollway et al., 2007
muscle cell migration disrupted, abnormal	WT + MO4-cxcl12a	standard conditions	Fig. S5 from Hollway et al., 2007
somite cellular quality, abnormal	WT + MO4-cxcl12a	standard conditions	Fig. 6 from Hollway et al., 2007
axon guidance process quality, abnormal	WT + MO4-cxcl12a	standard conditions	Fig. S4 from Hollway et al., 2007

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Citations

Include unpublished citations

Westerich, K.J., Reinecke, S., Emich, J., Wyrwoll, M.J., Stallmeyer, B., Meyer, M., Oud, M.S., Fietz, D., Pilatz, A., Kliesch, S., Reichman-Fried, M., Tarbashevich, K., Limon, T., Stehling, M., Friedrich, C., Tüttelmann, F., Raz, E. (2023) Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Human reproduction (Oxford, England). 38(4):655-670
Truszkowski, L., Batur, D., Long, H., Tarbashevich, K., Vos, B.E., Trappmann, B., Raz, E. (2022) Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. Development (Cambridge, England). 150(2):
Marsay, K.S., Greaves, S., Mahabaleshwar, H., Ho, C.M., Roehl, H., Monk, P.N., Carney, T.J., Partridge, L.J. (2021) Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS One. 16:e0260372
Olguin-Olguin, A., Aalto, A., Maugis, B., Boquet-Pujadas, A., Hoffmann, D., Ermlich, L., Betz, T., Gov, N.S., Reichman-Fried, M., Raz, E. (2021) Chemokine-biased robust self-organizing polarization of migrating cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118(7):
Malhotra, D., Shin, J., Solnica-Krezel, L., Raz, E. (2018) Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLIFE. 7
Neelathi, U.M., Dalle Nogare, D., Chitnis, A.B. (2018) Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.. Development (Cambridge, England). 145(14):
Gross-Thebing, T., Yigit, S., Pfeiffer, J., Reichman-Fried, M., Bandemer, J., Ruckert, C., Rathmer, C., Goudarzi, M., Stehling, M., Tarbashevich, K., Seggewiss, J., Raz, E. (2017) The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Developmental Cell. 43:704-715.e5
Paksa, A., Bandemer, J., Hoeckendorf, B., Razin, N., Tarbashevich, K., Minina, S., Meyen, D., Biundo, A., Leidel, S.A., Peyrieras, N., Gov, N.S., Keller, P.J., Raz, E. (2016) Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nature communications. 7:11288
Meyen, D., Tarbashevich, K., Banisch, T.U., Wittwer, C., Reichman-Fried, M., Maugis, B., Grimaldi, C., Messerschmidt, E.M., Raz, E. (2015) Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. eLIFE. 4
Tarbashevich, K., Reichman-Fried, M., Grimaldi, C., Raz, E. (2015) Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Current biology : CB. 25(8):1096-103

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