ZFIN Morpholino: MO2-wnt11f2

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-wnt11f2

No data available

Phenotype

Phenotype resulting from MO2-wnt11f2

Phenotype	Fish	Figures
axis decreased length, abnormal	TU + MO2-wnt11f2	Fig. 7 from Yao et al., 2008
convergent extension disrupted, abnormal	AB + MO2-wnt11f2	Fig. Table 2 from Matsui et al., 2005
convergent extension process quality, abnormal	WT + MO2-wnt11f2	Fig. 3 from Bai et al., 2014
convergent extension involved in axis elongation disrupted, abnormal	TU + MO2-wnt11f2	Fig. 7 from Yao et al., 2008
convergent extension involved in gastrulation disrupted, abnormal	TU + MO2-wnt11f2	Fig. 7 from Yao et al., 2008

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Phenotype of all Fish created by or utilizing MO2-wnt11f2

Phenotype	Fish	Conditions	Figures
convergent extension disrupted, abnormal	AB + MO2-wnt11f2	standard conditions	Fig. Table 2 from Matsui et al., 2005
convergent extension involved in axis elongation disrupted, abnormal	TU + MO2-wnt11f2	standard conditions	Fig. 7 from Yao et al., 2008
convergent extension involved in gastrulation disrupted, abnormal	TU + MO2-wnt11f2	standard conditions	Fig. 7 from Yao et al., 2008
notochord increased width, abnormal	TU + MO2-wnt11f2	standard conditions	Fig. 7 from Yao et al., 2008
post-anal tail morphogenesis disrupted, abnormal	TU + MO2-wnt11f2	standard conditions	Fig. 7 from Yao et al., 2008

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Citations

Include unpublished citations

De Jong, H.N., Dewey, F.E., Cordero, P., Victorio, R.A., Kirillova, A., Huang, Y., Madhvani, R., Seo, K., Werdich, A.A., Lan, F., Orcholski, M., Robert Liu, W., Erbilgin, A., Wheeler, M.T., Chen, R., Pan, S., Kim, Y.M., Bommakanti, K., Marcou, C.A., Martijn Bos, J., Haddad, F., Ackerman, M., Vasan, R.S., MacRae, C., Wu, J.C., de Jesus Perez, V., Snyder, M., Parikh, V.N., Ashley, E.A. (2022) Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circulation. Genomic and precision medicine. 15(4):e003563
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Bai, Y., Tan, X., Zhang, H., Liu, C., Zhao, B., Li, Y., Lu, L., Liu, Y., Zhou, J. (2014) Ror2 Receptor Mediates Wnt11 Signaling and Affects Convergence and Extension Movements in Zebrafish. The Journal of biological chemistry. 289(30):20664-20676
Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
Young, T., Poobalan, Y., Tan, E.K., Tao, S., Ong, S., Wehner, P., Schwenty-Lara, J., Lim, C.Y., Sadasivam, A., Lovatt, M., Wang, S.T., Ali, Y., Borchers, A., Sampath, K., Dunn, N.R. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development (Cambridge, England). 141:3505-16
Panáková, D., Werdich, A.A., and MacRae, C.A. (2010) Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 466(7308):874-878
Pei, W., and Feldman, B. (2009) Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Developmental Biology. 326(1):201-211
Vervenne, H.B., Crombez, K.R., Lambaerts, K., Carvalho, L., Koeppen, M., Heisenberg, C.P., Van de Ven, W.J., and Petit, M.M. (2008) Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Developmental Biology. 320(1):267-277
Yao, S., Xie, L., Qian, M., Yang, H., Zhou, L., Zhou, Q., Yan, F., Gou, L., Wei, Y., Zhao, X., and Mo, X. (2008) Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS letters. 582(15):2325-2332
Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175

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