ZFIN Lab: Ahrens Lab

ZFIN ID: ZDB-LAB-130116-1

Ahrens Lab

PI/Director:	Ahrens, Misha
Contact Person:	Narayan, Sujatha
Email:	narayans@janelia.hhmi.org
URL:	http://ahrenslab.org/
Address:	HHMI Janelia Research Campus 19700 Helix Drive - Office 2E.150 Ashburn, VA 20147
Country:	United States
Phone:	571.209.4000
Fax:	571-209-4945
Line Designation:	jf

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 24 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Kawashima, Takashi Post-Doc	Mu, Yu Post-Doc	Bennett, Davis Graduate Student
Narayan, Sujatha Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Yang, E., Zwart, M.F., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B.D., Fitzgerald, J.E., Ahrens, M.B. (2022) A brainstem integrator for self-location memory and positional homeostasis in zebrafish. Cell. 185:50115027.e205011-5027.e20

Böhm, U.L., Kimura, Y., Kawashima, T., Ahrens, M.B., Higashijima, S.I., Engert, F., Cohen, A.E. (2022) Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish. Neuron. 110(7):1211-1222.e4

Mu, Y., Narayan, S., Mensh, B.D., Ahrens, M.B. (2020) Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish. Current opinion in neurobiology. 64:151-160

Shemesh, O.A., Linghu, C., Piatkevich, K.D., Goodwin, D., Celiker, O.T., Gritton, H.J., Romano, M.F., Gao, R., Yu, C.J., Tseng, H.A., Bensussen, S., Narayan, S., Yang, C.T., Freifeld, L., Siciliano, C.A., Gupta, I., Wang, J., Pak, N., Yoon, Y.G., Ullmann, J.F.P., Guner-Ataman, B., Noamany, H., Sheinkopf, Z.R., Park, W.M., Asano, S., Keating, A.E., Trimmer, J.S., Reimer, J., Tolias, A.S., Bear, M.F., Tye, K.M., Han, X., Ahrens, M.B., Boyden, E.S. (2020) Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator. Neuron. 107(3):470-486.e11

Zarowny, L., Aggarwal, A., Rutten, V.M.S., Kolb, I., Project, T.G., Patel, R., Huang, H.Y., Chang, Y.F., Phan, T., Kanyo, R., Ahrens, M.B., Allison, W.T., Podgorski, K., Campbell, R.E. (2020) A bright and high-performance genetically encoded Ca2+ indicator based on mNeonGreen fluorescent protein. ACS sensors. 5(7):1959-1968

Hamanaka, K., Imagawa, E., Koshimizu, E., Miyatake, S., Tohyama, J., Yamagata, T., Miyauchi, A., Ekhilevitch, N., Nakamura, F., Kawashima, T., Goshima, Y., Mohamed, A.R., Ch'ng, G.S., Fujita, A., Azuma, Y., Yasuda, K., Imamura, S., Nakashima, M., Saitsu, H., Mitsuhashi, S., Mizuguchi, T., Takata, A., Miyake, N., Matsumoto, N. (2020) De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. American journal of human genetics. 106(4):549-558

Ahrens, M.B. (2019) Zebrafish Neuroscience: Using Artificial Neural Networks to Help Understand Brains. Current biology : CB. 29:R1138-R1140

Wee, C.L., Song, E.Y., Johnson, R.E., Ailani, D., Randlett, O., Kim, J.Y., Nikitchenko, M., Bahl, A., Yang, C.T., Ahrens, M.B., Kawakami, K., Engert, F., Kunes, S. (2019) A bidirectional network for appetite control in larval zebrafish. eLIFE. 8:

Abdelfattah, A.S., Kawashima, T., Singh, A., Novak, O., Liu, H., Shuai, Y., Huang, Y.C., Campagnola, L., Seeman, S.C., Yu, J., Zheng, J., Grimm, J.B., Patel, R., Friedrich, J., Mensh, B.D., Paninski, L., Macklin, J.J., Murphy, G.J., Podgorski, K., Lin, B.J., Chen, T.W., Turner, G.C., Liu, Z., Koyama, M., Svoboda, K., Ahrens, M.B., Lavis, L.D., Schreiter, E.R. (2019) Bright and photostable chemigenetic indicators for extended in vivo voltage imaging. Science (New York, N.Y.). 365(6454):699-704

Marvin, J.S., Shimoda, Y., Magloire, V., Leite, M., Kawashima, T., Jensen, T.P., Kolb, I., Knott, E.L., Novak, O., Podgorski, K., Leidenheimer, N.J., Rusakov, D.A., Ahrens, M.B., Kullmann, D.M., Looger, L.L. (2019) A genetically encoded fluorescent sensor for in vivo imaging of GABA. Nature Methods. 16(8):763-770

Mu, Y., Bennett, D.V., Rubinov, M., Narayan, S., Yang, C.T., Tanimoto, M., Mensh, B.D., Looger, L.L., Ahrens, M.B. (2019) Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior. Cell. 178(1):27-43.e19

Vladimirov, N., Wang, C., Höckendorf, B., Pujala, A., Tanimoto, M., Mu, Y., Yang, C.T., Wittenbach, J.D., Freeman, J., Preibisch, S., Koyama, M., Keller, P.J., Ahrens, M.B. (2018) Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function. Nature Methods. 15:1117-1125

Chen, X., Mu, Y., Hu, Y., Kuan, A.T., Nikitchenko, M., Randlett, O., Chen, A.B., Gavornik, J.P., Sompolinsky, H., Engert, F., Ahrens, M.B. (2018) Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish. Neuron. 100:876-890.e5

Piatkevich, K.D., Jung, E.E., Straub, C., Linghu, C., Park, D., Suk, H.J., Hochbaum, D.R., Goodwin, D., Pnevmatikakis, E., Pak, N., Kawashima, T., Yang, C.T., Rhoades, J.L., Shemesh, O., Asano, S., Yoon, Y.G., Freifeld, L., Saulnier, J.L., Riegler, C., Engert, F., Hughes, T., Drobizhev, M., Szabo, B., Ahrens, M.B., Flavell, S.W., Sabatini, B.L., Boyden, E.S. (2018) A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Nature Chemical Biology. 14(4):352-360

Vanwalleghem, G.C., Ahrens, M.B., Scott, E.K. (2018) Integrative whole-brain neuroscience in larval zebrafish. Current opinion in neurobiology. 50:136-145

Friedrich, J., Yang, W., Soudry, D., Mu, Y., Ahrens, M.B., Yuste, R., Peterka, D.S., Paninski, L. (2017) Multi-scale approaches for high-speed imaging and analysis of large neural populations. PLoS Computational Biology. 13:e1005685

Kawashima, T., Zwart, M.F., Yang, C.T., Mensh, B.D., Ahrens, M.B. (2016) The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning. Cell. 167:933-946.e20

Dana, H., Mohar, B., Sun, Y., Narayan, S., Gordus, A., Hasseman, J.P., Tsegaye, G., Holt, G.T., Hu, A., Walpita, D., Patel, R., Macklin, J.J., Bargmann, C.I., Ahrens, M.B., Schreiter, E.R., Jayaraman, V., Looger, L.L., Svoboda, K., Kim, D.S. (2016) Sensitive red protein calcium indicators for imaging neural activity. eLIFE. 5

Dunn, T.W., Mu, Y., Narayan, S., Randlett, O., Naumann, E.A., Yang, C.T., Schier, A.F., Freeman, J., Engert, F., Ahrens, M.B. (2016) Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion. eLIFE. 5:e12741

Quirin, S., Vladimirov, N., Yang, C.T., Peterka, D.S., Yuste, R., Ahrens, M. B. (2016) Calcium imaging of neural circuits with extended depth-of-field light-sheet microscopy. Optics letters. 41:855-858

Dunn, T.W., Gebhardt, C., Naumann, E.A., Riegler, C., Ahrens, M.B., Engert, F., Del Bene, F. (2016) Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. Neuron. 89(3):613-28

Bennett, D.V., Ahrens, M.B. (2016) A Practical Guide to Light Sheet Microscopy. Methods in molecular biology (Clifton, N.J.). 1451:321-31

Fosque, B.F., Sun, Y., Dana, H., Yang, C.T., Ohyama, T., Tadross, M.R., Patel, R., Zlatic, M., Kim, D.S., Ahrens, M.B., Jayaraman, V., Looger, L.L., Schreiter, E.R. (2015) Labeling of active neural circuits in vivo with designed calcium integrators. Science (New York, N.Y.). 347:755-760

Keller, P.J., Ahrens, M.B., Freeman, J. (2015) Light-sheet imaging for systems neuroscience. Nature Methods. 12:27-9

Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N.J., Bennett, D.V., Rosen, J., Yang, C.T., Looger, L.L., Ahrens, M.B. (2014) Mapping brain activity at scale with cluster computing. Nature Methods. 11(9):941-50

Vladimirov, N., Mu, Y., Kawashima, T., Bennett, D.V., Yang, C.T., Looger, L.L., Keller, P.J., Freeman, J., Ahrens, M.B. (2014) Light-sheet functional imaging in fictively behaving zebrafish. Nature Methods. 11(9):883-4

Huang, K.H., Ahrens, M.B., Dunn, T.W., and Engert, F. (2013) Spinal Projection Neurons Control Turning Behaviors in Zebrafish. Current biology : CB. 23(16):1566-73

Ahrens, M.B., Huang, K.H., Narayan, S., Mensh, B.D., and Engert, F. (2013) Two-photon calcium imaging during fictive navigation in virtual environments. Frontiers in neural circuits. 7:104

Ahrens, M.B., Orger, M.B., Robson, D.N., Li, J.M., and Keller, P.J. (2013) Whole-brain functional imaging at cellular resolution using light-sheet microscopy. Nature Methods. 10(5):413-20

Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843

Mu, Y., Li, X.Q., Zhang, B., and Du, J.L. (2012) Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism. Neuron. 75(4):688-699

Han, Y., Mu, Y., Li, X., Xu, P., Tong, J., Liu, Z., Ma, T., Zeng, G., Yang, S., Du, J., and Meng, A. (2011) Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Human molecular genetics. 20(16):3213-26