ZFIN ID: ZDB-LAB-110912-2
Nieto Lab
PI/Director: Nieto, Angela
Co-PI / Senior
Galceran, Juan
Contact Person: Galceran, Juan
Email: anieto@umh.es
URL: http://in.umh.es/grupos-detalle.aspx?grupo=43
Address: Instituto de Neurociencias. CSIC-UMH Avda Ramón y Cajal, s/n 03550 San Juan de Alicante, Alicante (Spain)
Country: Spain
Phone: +34 965 91 92 43
Fax: +34 965 91 95 61
Line Designation: in

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Our research group has been studying cell movements and plasticity more than 20 years. In particular, we have studied the epithelial to mesenchymal transition (EMT) during embryonic development and our main contribution has been the impact that the reactivation of this developmental program has in adult disease. We first studied the connection with tumour progression and, in the last ten years, we have extended our studies to pathologies related to bone development and homeostasis and also organ degeneration (EMBO J 2006, 2009; Dev Cell 2007, 2011; Cancer Cell 2012; Nat Med 2015).
Our interest in cell behaviour and cell movements in vivo led us to use the zebrafish as a fundamental model system, while we continue to use the chicken and mouse as additional experimental models. We also study cultured cells and samples from patients affected by the pathologies for which we have developed animal models.
With respect to cancer progression, we have shown that EMT/MET plasticity is required for migratory cancer cells to form metastases. In non-transformed cells, we have reported that the reactivation of a partial EMT is sufficient and required in fibrosis and importantly, established disease can be reversed by therapeutic treatment with EMT inhibitors. The latter opens new avenues in anti-fibrotic therapies. For recent reviews on our main theme see Nieto, Science, 2013, and Nieto et al., Cell 2016.

We are currently interested in (i)unveiling and testing novel regulatory networks that control cell movements and plasticity, (ii) identifying protein domains/modules that convey functional evolution of cell behaviour, (iii) following cell movements during embryonic development and cancer cells from the primary tumour to the metastatic foci.

Ocaña, Oscar H. Post-Doc Salgado Almario, Jussep Post-Doc Sánchez-Laorden, Berta Post-Doc
Vega, Sonia Post-Doc Youssef, KK Post-Doc Gomez-Martinez, Teresa Technical Staff
López-Blau, Cristina Technical Staff

Castroviejo, N., Ocaña, O.H., Rago, L., Coskun, H., Arcas, A., Galcerán, J., Nieto, M.A. (2020) Reply to: Zebrafish prrx1a mutants have normal hearts. Nature. 585:E17-E19
Rago, L., Castroviejo, N., Fazilaty, H., Garcia-Asencio, F., Ocaña, O.H., Galcerán, J., Nieto, M.A. (2019) MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Developmental Cell. 51:446-459.e5
Fazilaty, H., Rago, L., Kass Youssef, K., Ocaña, O.H., Garcia-Asencio, F., Arcas, A., Galceran, J., Nieto, M.A. (2019) A gene regulatory network to control EMT programs in development and disease. Nature communications. 10:5115
Ocaña, O.H., Coskun, H., Minguillón, C., Murawala, P., Tanaka, E.M., Galcerán, J., Muñoz-Chápuli, R., Nieto, M.A. (2017) A right-handed signalling pathway drives heart looping in vertebrates. Nature. 549:86-90
Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474
Rodríguez-Aznar, E., Barrallo-Gimeno, A., and Nieto, M.A. (2013) Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(12):5095-5105
Ocaña, O.H., Córcoles, R., Fabra, A., Moreno-Bueno, G., Acloque, H., Vega, S.,Barrallo-Gimeno, A., Cano, A., Nieto, M.A. (2012) Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1. Cancer Cell. 22(6):709-724
Zhang, K., Rodriguez-Aznar, E., Yabuta, N., Owen, R.J., Mingot, J.M., Nojima, H., Nieto, M.A., and Longmore, G.D. (2012) Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. The EMBO journal. 31(1):29-43
Rodríguez-Aznar, E., and Nieto, M.A. (2011) Repression of Puma by Scratch2 is required for neuronal survival during embryonic development. Cell death and differentiation. 18(7):1196-207
Blanco, M.J., Barrallo-Gimeno, A., Acloque, H., Reyes, A.E., Tada, M., Allende, M.L., Mayor, R., and Nieto, M.A. (2007) Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (Cambridge, England). 134(22):4073-4081
Manzanares, M., Blanco, M.J., and Nieto, M.A. (2004) Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family. Development genes and evolution. 214(1):47-53
Locascio, A., Manzanares, M., Blanco, M.J., and Nieto, M.A. (2002) Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16841-16846