Lab
Spaink Lab
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Statement of Research Interest
Signaling dynamics underlying innate immunity and cancer in the zebrafish embryo model
Lab Members
| Boland, Ralf Post-Doc | Koch, Bjorn Post-Doc | van der Vaart, Michiel Post-Doc |
| Rueb, Saskia Technical Staff |
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Nurhidayat, L., Benes, V., Blom, S., Gomes, I., Firdausi, N., de Bakker, M.A.G., Spaink, H.P., Richardson, M.K. (2025) Tokay gecko tail regeneration involves temporally collinear expression of HOXC genes and early expression of satellite cell markers. BMC Biology. 23:66
- Antunes, S.S., Forn-Cuní, G., Romeiro, N.C., Spaink, H.P., Verbeek, F.J., Muzitano, M.F. (2024) Embryonic and larval zebrafish models for the discovery of new bioactive compounds against TB. Drug discovery today. 29(11):104163
- Araujo, M.H., Muñoz Sánchez, S., Simão, T.L.B.V., Nowik, N., Antunes, S.S., Pinto, S.C., Sorze, D., Boldrin, F., Manganelli, R., Correia Romeiro, N., Lasunskaia, E.B., Verbeek, F.J., Spaink, H.P., Muzitano, M.F. (2024) Exploring the Antimycobacterial Potential of Podocarpusflavone A from Kielmeyera membranacea: In Vitro and In Vivo Insights. Pharmaceuticals (Basel, Switzerland). 17(12):
- Del Prado, J.A., Ding, Y., Sonneville, J., der Kolk, K.V., Moreno-Mateos, M.A., Málaga-Trillo, E., Spaink, H.P. (2024) Comparing robotic and manual injection methods in zebrafish embryos for high-throughput RNA silencing using CRISPR-RfxCas13d. Biotechniques. 76(5):183-191
- Dirks, R.P., Ordas, A., Jong-Raadsen, S., Brittijn, S.A., Haks, M.C., Henkel, C.V., Oravcova, K., Racz, P.I., Tuinhof-Koelma, N., Korzeniowska Nee Wiweger, M.I., Gillespie, S.H., Meijer, A.H., Ottenhoff, T.H.M., Jansen, H.J., Spaink, H.P. (2024) The Human Pathogen Mycobacterium tuberculosis and the Fish Pathogen Mycobacterium marinum Trigger a Core Set of Late Innate Immune Response Genes in Zebrafish Larvae. Biology. 13(9):
- Kilinç, G., Boland, R., Heemskerk, M.T., Spaink, H.P., Haks, M.C., van der Vaart, M., Ottenhoff, T.H.M., Meijer, A.H., Saris, A. (2024) Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy. Microbiology spectrum. 12(8):e0016724
- Singer, R., Oganezova, I., Hu, W., Ding, Y., Papaioannou, A., de Groot, H.J.M., Spaink, H.P., Alia, A. (2024) Unveiling the Exquisite Microstructural Details in Zebrafish Brain Non-Invasively Using Magnetic Resonance Imaging at 28.2 T. Molecules. 29(19):
- Singer, R., Oganezova, I., Hu, W., Liu, L., Ding, Y., de Groot, H.J.M., Spaink, H.P., Alia, A. (2024) Ultrahigh field diffusion magnetic resonance imaging uncovers intriguing microstructural changes in the adult zebrafish brain caused by Toll-like receptor 2 genomic deletion. NMR in Biomedicine. 37(10):e5170
- Allers, M., Bakker, P.A., Hoeksma, J., Spaink, H.P., den Hertog, J. (2023) Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Disease models & mechanisms. 16(2):
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